Volume 25 Issue 6, June 2019
Brief Communication | 03 June 2019
CCR5-∆32 is deleterious in the homozygous state in humans
Individuals homozygous for the CCR5-∆32 allele have a 21% increase in mortality rate in the UK Biobank cohort. In light of the CRISPR-baby scandal, this work highlights the need for understanding the unintended consequences of introducing mutations in humans.
Xinzhu Wei & Rasmus Nielsen