PNAS – Proceedings of the National Academy of Sciences of the United States of America
January 19, 2021 118 (3)
Perspective Open Access
Vaccinology in the post−COVID-19 era
Rino Rappuoli, Ennio De Gregorio, Giuseppe Del Giudice, Sanjay Phogat, Simone Pecetta, Mariagrazia Pizza, and Emmanuel Hanon
PNAS January 19, 2021 118 (3) e2020368118; https://doi.org/10.1073/pnas.2020368118
The COVID-19 pandemic is a shocking reminder of how our world would look in the absence of vaccination. Fortunately, new technologies, the pace of understanding new and existing pathogens, and the increased knowledge of the immune system allow us today to develop vaccines at an unprecedented speed. Some of the vaccine technologies that are fast-tracked by the urgency of COVID-19 may also be the answer for other health priorities, such as antimicrobial resistance, chronic infections, and cancer, that the post-COVID-19 world will urgently need to face. This perspective analyzes the way COVID-19 is transforming vaccinology and the opportunities for vaccines to have an increasingly important role in health and well-being.