JAMA
Vol. 301 No. 10, pp. 997-1086, March 11, 2009
http://jama.ama-assn.org/current.dtl

The Evolution of Influenza Resistance and Treatment
David M. Weinstock, MD; Gianna Zuccotti, MD
JAMA. 2009;301(10):1066-1069. Published online March 2, 2009 (doi:10.1001/jama.2009.324).

[Concluding paragraph]
“… The understanding of influenza biology and epidemiology has advanced markedly; however, the global dissemination of oseltamivir-resistant influenza came as a great surprise. Undoubtedly, new surprises await in the perpetual struggle with influenza as one thing is certain-the organism will continue to evolve. Anticipating the rapid and endless changes in influenza biology and dynamics will require faster diagnostics to molecularly characterize specimens, extensive surveillance among humans and animals, and more rapid and malleable systems for translating basic and epidemiological discoveries into clinically applicable interventions. For now, the best tools to mitigate influenza infection are tried-and-true-vaccination, social distancing, hand washing, and common sense.”