Vaccine
Volume 27, Issue 40, Pages 5429-5542 (4 September 2009)
http://www.sciencedirect.com/science/journal/0264410X

Cost-effectiveness analysis of a cervical cancer vaccine in five Latin American countries
Pages 5519-5529
Lisandro Colantonio, Jorge A. Gómez, Nadia Demarteau, Baudouin Standaert, Andrés Pichón-Rivière, Federico Augustovski

Abstract
Implementation of cervical cancer (CC) vaccination in Latin America is expected to reduce the high CC burden in those countries. But the efficiency of such vaccination programs in the region still remains unknown. This study assesses the cost-effectiveness and cost-utility of introducing vaccination into the current CC disease management of five Latin American countries (Argentina, Brazil, Chile, Mexico, and Peru). The modelling results indicate that universal mass vaccination is cost-effective in the current health care setting of each country (<3× gross domestic product per capita, per country) with a substantial number of CC cases and deaths avoided in addition to an increase of quality-adjusted life years. This study will help guide the design of future clinical programmes and health-related policies. It will assist early and effective decision-making processes related to vaccine implementation in Latin America.