New England Journal of Medicine
November 18, 2010  Vol. 363 No. 21
http://content.nejm.org/current.shtml

Review Article
Current Concepts: Influenza Vaccines for the Future
L.C. Lambert, A.S. Fauci
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…Conclusions
Although the past decade has witnessed considerable improvements in our approach to the development of influenza vaccines, much still needs to be done. Although converting from egg-based to cell-based systems and adding adjuvants to enhance protective immune responses are important steps in the right direction, it is the new vaccine technologies that hold the promise of revolutionizing influenza vaccinology. Over the next decade, advances are anticipated that will substantially decrease vaccine production time, provide enhanced protection (especially in populations at greatest risk), and end mismatches between vaccine strains and circulating viruses. To fully reap the benefits as progress is made in developing new vaccines, we will need both clear regulatory guidance on pathways for their approval and a robust and agile infrastructure to ensure their timely production and equitable distribution.