The Lancet
Jan 29, 2011  Volume 377 Number 9763 Pages 353 – 438
http://www.thelancet.com/journals/lancet/issue/current

Dengue vaccine prospects: a step forward
Bruno Guy, Jeffrey Almond, Jean Lang

Preview
The worldwide expansion of dengue fever is a growing health problem. Crucial issues surround this global expansion and some of them present some challenges for vaccine development. Nevertheless, several promising approaches are being investigated in both academic and industrial laboratories.1 Vaccine candidates include live, attenuated vaccines obtained via cell passages or by recombinant DNA technology (such as those being developed by the US National Institutes of Allergy and Infectious Diseases, InViragen, Walter Reed Army Institute of Research/GlaxoSmithKline, and Sanofi Pasteur), and subunit vaccines (such as those developed by Merck/Hawaii Biotech).