Nature Medicine
February 2011, Volume 17 No 2
http://www.nature.com/nm/index.html

News and Views
Tuberculosis vaccines—a new kid on the block
Stefan H E Kaufmann
doi:10.1038/nm0211-159

New tuberculosis vaccines are urgently needed to reduce the threat of this devastating disease. An approach consisting of a fusion protein of three tuberculosis antigens provides significant protection in before- and after-exposure challenge mouse models, representing a crucial step forward in tackling tuberculosis in latently infected individuals

Articles
A multistage tuberculosis vaccine that confers efficient protection before and after exposure
Claus Aagaard, Truc Hoang, Jes Dietrich, Pere-Joan Cardona, Angelo Izzo, Gregory Dolganov, Gary K Schoolnik, Joseph P Cassidy, Rolf Billeskov & Peter Andersen
doi:10.1038/nm.2285

There is an essential need for vaccines that can prevent primary infection by Mycobacterium tuberculosis and control its reactivation in individuals with latent disease. Claus Aagaard et al. now report the development of a dual-function vaccine that shows protective efficacy in mice by both inhibiting infection upon initial pathogen exposure and by impairing reactivation of latent infection with M. tuberculosis.