The Lancet Infectious Disease
Aug 2011  Volume 11  Number 8  p579 – 650
http://www.thelancet.com/journals/laninf/issue/current

Fact and fiction in tuberculosis vaccine research: 10 years later
Stefan HE Kaufmann

Preview
Tuberculosis is one of the most deadly infectious diseases. The situation is worsening because of co-infection with HIV and increased occurrence of drug resistance. Although the BCG vaccine has been in use for 90 years, protection is insufficient; new vaccine candidates are therefore needed. 12 potential vaccines have gone into clinical trials. Ten are aimed at prevention of tuberculosis and, of these, seven are subunit vaccines either as adjuvanted or viral-vectored antigens. These vaccines would be boosters of BCG-prime vaccination.