Annals of Internal Medicine
December 6, 2011; 155 (11)
http://www.annals.org/content/current

Original Research
Maternal Immune Response and Neonatal Seroprotection From a Single Dose of a Monovalent Nonadjuvanted 2009 Influenza A(H1N1) Vaccine: A Single-Group Trial
Vassilis Tsatsaris, Catherine Capitant, Thomas Schmitz, Corine Chazallon, Sophie Bulifon, Didier Riethmuller, Olivier Picone, Patrice Poulain, Fanny Lewin, Fabrice Lainé, Evelyne Jacqz-Aigrain, Jean-Pierre Aboulker, and Odile Launay, for the Inserm C09-33 PREFLUVAC (Immunogenicity and Safety of an Inactivated Nonadjuvanted A[H1N1v] Influenza Vaccine in Pregnant Women) Study Group
Ann Intern Med December 6, 2011 155:733-741;

Summary
Pregnant women and infants who get influenza are at increased risk for severe illness. In this prospective, multicenter, single-group clinical trial from France, nearly all women who received a single dose of a nonadjuvant 2009 influenza A(H1N1) vaccine in their second and third trimesters had antibody titers that were considered protective. Antibody titers in cord blood samples from 95% of the infants were also at a level considered protective. A single dose of influenza vaccine administered to women during pregnancy should protect both mothers and their newborns.