Science Translational Medicine
4 January 2012 vol 4, issue 115
http://stm.scienceag.org/content/mcurrent

Focus: Hepatitis C Virus
Chimp Virus Makes a Savvy Vaccine Vector
Michael Houghton
4 January 2012: 115fs1
Abstract
A hepatitis C virus vaccine delivered by a chimpanzee-derived adenovirus vector produces strong T cell immune responses in healthy human volunteers.

Research Articles
Hepatitis C
Novel Adenovirus-Based Vaccines Induce Broad and Sustained T Cell Responses to HCV in Man
Eleanor Barnes, Antonella Folgori, Stefania Capone, Leo Swadling, Stephen Aston, Ayako Kurioka, Joel Meyer, Rachel Huddart, Kira Smith, Rachel Townsend, Anthony Brown, Richard Antrobus, Virginia Ammendola, Mariarosaria Naddeo, Geraldine O’Hara, Chris Willberg, Abby Harrison, Fabiana Grazioli, Maria Luisa Esposito, Loredana Siani, Cinzia Traboni, Ye Oo, David Adams, Adrian Hill, Stefano Colloca, Alfredo Nicosia, Riccardo Cortese, and Paul Klenerman
4 January 2012: 115ra1
An adenoviral HCV vaccine induces antiviral T cell responses in human volunteers.

Gene therapy
Vaccine Vectors Derived from a Large Collection of Simian Adenoviruses Induce Potent Cellular Immunity Across Multiple Species
Stefano Colloca, Eleanor Barnes, Antonella Folgori, Virginia Ammendola, Stefania Apone, Agostino Cirillo, Loredana Siani, Mariarosaria Naddeo, Fabiana Grazioli, Maria Luisa Esposito, Maria Ambrosio, Angela Sparacino, Marta Bartiromo, Annalisa Meola, Kira Smith, Ayako Kurioka, Geraldine A. O’Hara, Katie J. Ewer, Nicholas Anagnostou, Carly Bliss, Adrian V. S. Hill, Cinzia Traboni, Paul Klenerman, Riccardo Cortese, and Alfredo Nicosia
4 January 2012: 115ra2
Simian adenoviruses screened from wild-derived candidates can prime T cell responses in man and may serve as new vaccine vector candidates.