Vaccine
http://www.sciencedirect.com/science/journal/0264410X
Volume 30, Issue 33 pp. 4897-5058 (13 July 2012)

Reviews
New technologies for new influenza vaccines
Review Article
Pages 4927-4933
Alan Shaw

Abstract
The currently available influenza vaccines were developed in the 1930s through the 1960s using technologies that were state-of-the art for the times. Decades of advancement in virology and immunology have provided the tools for making better vaccines against influenza. We now have the means to make vaccines that address some of the shortcomings of the original products, in particular performance in the elderly.