The Lancet  
Sep 15, 2012  Volume 380  Number 9846  p949 – 1030  e2 – 6
http://www.thelancet.com/journals/lancet/issue/current

Comment
Treatment of tuberculosis: have we turned the corner?
Giovanni Battista Migliori, Giovanni Sotgiu

Preview
The number of multidrug-resistant (MDR) tuberculosis cases officially reported to WHO increased from 29 000 to 53 000 between 2008 and 2010,1 still representing only 18% of the estimated 290 000 patients potentially identifiable if drug susceptibility testing was done in all notified cases of tuberculosis.1 A recent study done in Belarus2 showed a new global record for prevalence of MDR tuberculosis with 35·3% of new patients and 76·5% of previously treated patients diagnosed with the disease. This finding clearly shows how far case mismanagement can affect the chances to control (and eventually eliminate) the disease.