Effect of intermittent preventive treatment for malaria during infancy on serological responses to measles and other EPI vaccines

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The Lancet  
Sep 15, 2012  Volume 380  Number 9846  p949 – 1030  e2 – 6
http://www.thelancet.com/journals/lancet/issue/current

Articles
Effect of intermittent preventive treatment for malaria during infancy on serological responses to measles and other vaccines used in the Expanded Programme on Immunization: results from five randomised controlled trials
Jane Crawley, Charalambos Sismanidis, Tracey Goodman, Paul Milligan, WHO Advisory Committee on serological responses to vaccines used in the Expanded Programme on Immunization in infants receiving Intermittent Preventive Treatment for malaria

Preview
IPTi with sulfadoxine-pyrimethamine does not affect serological responses to EPI vaccines. This analysis, therefore, supports the WHO recommendation for coadministration of IPTi with sulfadoxine-pyrimethamine to infants at the time of the second and third doses of DTP and measles vaccination, in areas of sub-Saharan Africa with moderate to high malaria transmission and where malaria parasites are sensitive to these drugs. It also suggests that treatment of clinical malaria at or around the time of vaccination does not compromise vaccine responsiveness.