JAMA   
April 03, 2013, Vol 309, No. 13
http://jama.ama-assn.org/current.dtl

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Ushering in a New Era of Open Science Through Data Sharing The Wall Must Come Down
Joseph S. Ross, MD, MHS; Harlan M. Krumholz, MD, SM
JAMA. 2013;309(13):1355-1356. doi:10.1001/jama.2013.1299.
http://jama.jamanetwork.com/article.aspx?articleid=1668313

Excerpt
It may appear that the clinical research enterprise is functioning well, even thriving. Nearly 30 000 trials globally are recruiting patients,1 and results from 75 trials are published daily in biomedical journals.2 However, there is a crisis, with an attendant opportunity, that requires change. A wall surrounds much of these clinical research data, sequestering knowledge, impeding the free flow of information, and obscuring a clear view of the totality of evidence relevant to many research questions and clinical decisions…