From Google Scholar & other sources: Selected Journal Articles, Dissertations, Theses, Commentary
Am J Trop Med Hyg 2013 13-0026
Community Diarrhea Incidence Before and After Rotavirus Vaccine Introduction in Nicaragua
Sylvia Becker-Dreps*, Marlon Meléndez, Lan Liu, Luís Enrique Zambrana, Margarita Paniagua, David J. Weber, Michael G. Hudgens, Mercedes Cáceres, Carina Källeståll, Douglas R. Morgan, Félix Espinoza and Rodolfo Peña
Published online July 1, 2013 , doi: 10.4269/ajtmh.13-0026
Abstract
We estimated the incidence of watery diarrhea in the community before and after introduction of the pentavalent rotavirus vaccine in León, Nicaragua. A random sample of households was selected before and after rotavirus vaccine introduction. All children < 5 years of age in selected households were eligible for inclusion. Children were followed every 2 weeks for watery diarrhea episodes. The incidence rate was estimated as numbers of episodes per 100 child-years of exposure time. A mixed effects Poisson regression model was fit to compare incidence rates in the pre-vaccine and vaccine periods. The pre-vaccine cohort (N = 726) experienced 36 episodes per 100 child-years, and the vaccine cohort (N = 826) experienced 25 episodes per 100 child-years. The adjusted incidence rate ratio was 0.60 (95% confidence interval [CI] 0.40, 0.91) during the vaccine period versus the pre-vaccine period, indicating a lower incidence of watery diarrhea in the community during the vaccine period.
Systems biological approaches to measure and understand vaccine immunity in humans
S Li, HI Nakaya, DA Kazmin, JZ Oh, B Pulendran – Seminars in Immunology, 2013
Highlights
:: Recent studies have used systems biological approaches to predict vaccine efficacy.
:: Such studies are yielding new insights about the mechanisms underlying vaccine immunity.
:: Data acquisition, management and modeling represent major challenges.
:: Integration of multiple “omics” data also represents major challenges.
:: Overcoming such challenges will enable systems approaches to guide rational vaccine design.
Abstract
Recent studies have demonstrated the utility of using systems approaches to identify molecular signatures that can be used to predict vaccine immunity in humans. Such approaches are now being used extensively in vaccinology, and are beginning to yield novel insights about the molecular networks driving vaccine immunity. In this review, we present a broad review of the methodologies involved in these studies, and discuss the promise and challenges involved in this emerging field of “systems vaccinology.”
A vaccine against Haemonchus contortus: current status and future possibilities.
D Knox, MW Kennedy, W Harnett – Parasitic nematodes: molecular biology, …, 2013
Abstract This chapter summarizes progress made in vaccine development against Haemonchus contortus infection, including discussions on lead vaccine antigens (ie, dipeptidyl peptidases, aminopeptidases, aspartyl and metalloproteases, cysteine …
Kicking against the pricks: vaccine sceptics have a different social orientation
J Luyten, P Desmet, V Dorgali, N Hens, P Beutels – The European Journal of Public …, 2013
Background: In any country, part of the population is sceptical about the utility of vaccination.
To develop successful vaccination programmes, it is important to study and understand the defining characteristics of vaccine sceptics. Research till now mainly focused either on the …
Report of the first Asia‐Pacific influenza summit, Asia‐Pacific Alliance for the Control of Influenza (APACI), Bangkok, 12–13 June 2012
LC Jennings, DW Smith, PKS Chan – Influenza and Other Respiratory Viruses, 2013
… The objectives of the meeting were to review the current state of official influenza control policies in Asia-Pacific countries; identify, summarize and communicate influenza control strategies that have successfully increased vaccine uptake in the region; develop policy and …
[PDF] Stability analysis of a general SIR epidemic model
R Ullah, G Zaman, S Islam – VFAST Transactions on Applied Mathematics, 2013
… Farrington [1] studied the impact of vacci- nation program on the transmission potential of the infection in large populations and obtained relation between vaccine efficacy against transmission, reproduction number and vaccine coverage. ..