Nature Medicine
December 2013, Volume 19 No 12 pp1547-1673
http://www.nature.com/nm/journal/v19/n12/index.html

Key roles of adjuvants in modern vaccines
Steven G Reed, Mark T Orr & Christopher B Fox
http://www.nature.com/nm/journal/v19/n12/abs/nm.3409.html

Abstract
Vaccines containing novel adjuvant formulations are increasingly reaching advanced development and licensing stages, providing new tools to fill previously unmet clinical needs. However, many adjuvants fail during product development owing to factors such as manufacturability, stability, lack of effectiveness, unacceptable levels of tolerability or safety concerns. This Review outlines the potential benefits of adjuvants in current and future vaccines and describes the importance of formulation and mechanisms of action of adjuvants. Moreover, we emphasize safety considerations and other crucial aspects in the clinical development of effective adjuvants that will help facilitate effective next-generation vaccines against devastating infectious diseases.