International Journal of Epidemiology
Volume 42 Issue 6 December 2013
http://ije.oxfordjournals.org/content/current

A new era in the history of cholera: the road to elimination
David A Sack
+ Author Affiliations
Department of International Health, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, Maryland 21205, USA. E-mail: dsack@jhsph.edu
http://ije.oxfordjournals.org/content/42/6/1537.extract

Excerpt
Historical background
One hundred and fifty years ago, Snow made the historic discovery that contaminated water transmitted cholera, but there were many other key discoveries and notable developments in the history of cholera. Koch cultured V. cholerae, the bacterium about which Snow could only speculate,1 and S.N. De discovered the enterotoxin produced by the bacterium resulting in massive outpouring of fluid.2 But these discoveries, by themselves, did not save the lives of cholera’s victims; 50% of them died until intravenous hydration therapy began to be used by Rogers in the early 1900s.3 This hypertonic intravenous solution reduced the case fatality rate, but not until the late 1950s and early 1960s were consistently successful treatments implemented based on careful intake and output balance studies…4,5

Reprints and Reflections
EA Parkes
Mode of Communication of Cholera. By John Snow, MD: Second Edition – London, 1855, pp 162.  Int. J. Epidemiol. (2013) 42 (6): 1543-1552 doi:10.1093/ije/dyt193 Extract

Tom Koch
Commentary: Nobody loves a critic: Edmund A Parkes and John Snow’s cholera  Int. J. Epidemiol. (2013) 42 (6): 1553-1559 doi:10.1093/ije/dyt194  Extract

John Eyler
Commentary: Confronting unexpected results: Edmund Parkes reviews John Snow
Int. J. Epidemiol. (2013) 42 (6): 1559-1562 doi:10.1093/ije/dyt195 Extract

Beverly P Bergman
Commentary: Edmund Alexander Parkes, John Snow and the miasma controversy
Int. J. Epidemiol. (2013) 42 (6): 1562-1565 doi:10.1093/ije/dyt212 Extract

Nigel Paneth
Commentary: Two views of cholera
Int. J. Epidemiol. (2013) 42 (6): 1565-1566 doi:10.1093/ije/dyt234 Extract

Reprints and Reflections
William Budd
Malignant Cholera: its cause, mode of propagation, and prevention
Int. J. Epidemiol. (2013) 42 (6): 1567-1575 doi:10.1093/ije/dyt204 Extract

Michael S Dunnill
Commentary: William Budd on cholera
Int. J. Epidemiol. (2013) 42 (6): 1576-1577 doi:10.1093/ije/dyt205  Extract

Robert Moorhead
Commentary: William Budd–a less well known human ecologist?
Int. J. Epidemiol. (2013) 42 (6): 1578-1579 doi:10.1093/ije/dyt222 Extract