PLoS One
[Accessed 8 February 2014]
http://www.plosone.org/

Overview
Methods to Assess the Impact of Mass Oral Cholera Vaccination Campaigns under Real Field Conditions
Jacqueline Deen mail, Mohammad Ali, David Sack
Published: February 07, 2014
DOI: 10.1371/journal.pone.0088139
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0088139

Abstract
There is increasing interest to use oral cholera vaccination as an additional strategy to water and sanitation interventions against endemic and epidemic cholera. There are two internationally-available and WHO-prequalified oral cholera vaccines: an inactivated vaccine containing killed whole-cells of V. cholerae O1 with recombinant cholera toxin B-subunit (WC/rBS) and a bivalent inactivated vaccine containing killed whole cells of V. cholerae O1 and V. cholerae O139 (BivWC). The efficacy, effectiveness, direct and indirect (herd) protection conferred by WC/rBS and BivWC are well established. Yet governments may need local evidence of vaccine impact to justify and scale-up mass oral cholera vaccination campaigns. We discuss various approaches to assess oral cholera vaccine protection, which may be useful to policymakers and public health workers considering deployment and evaluation of the vaccine.