Journal of Infectious Diseases
Volume 209 Issue 9 May 1, 2014
http://jid.oxfordjournals.org/content/current

A Case for Immunization of Human Papillomavirus (HPV) 6/11–Infected Pregnant Women With the Quadrivalent HPV Vaccine to Prevent Juvenile-Onset Laryngeal Papilloma
Keerti V. Shah
Author Affiliations
Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland
Presented in part: Second International Neonatal and Maternal Immunization Symposium, Antalya, Turkey, 1–3 March 2013.
http://jid.oxfordjournals.org/content/209/9/1307.abstract
Abstract
Juvenile-onset recurrent respiratory papillomatosis (JORRP) is a rare disease caused by intrapartum or perinatal transmission of human papillomavirus (HPV) types 6 and 11 from an infected mother to the newborn. Immunization of a pregnant woman who has condyloma or HPV-6/11 infection with the quadrivalent HPV vaccine will result in a high neutralizing antibody response to HPV 6 and HPV 11 in her serum, and these antibodies transferred to the newborn will likely protect the child against the development of JORRP. Because of the low incidence of disease in at-risk children, it may be difficult to test the effectiveness of maternal immunization for prevention of JORRP.