From Google Scholar+ [to 19 April 2014]

From Google Scholar & other sources: Selected Journal Articles, Newsletters, Dissertations, Theses, Commentary

Neurology
April 8, 2014 vol. 82 no. 10 Supplement S34.005
http://www.neurology.org/content/current
Vaccines and the Risk of Multiple Sclerosis and Other CNS Demyelinating Diseases (S34. 005)
Annette Langer-Gould1, Lie Chen2, Sara Tartof2, Chun Chao2 and Hung-Fu Tseng2
Abstract
OBJECTIVE: To determine whether vaccines increase the risk of multiple sclerosis (MS) or other CNS demyelinating diseases over the short and longer-term.
BACKGROUND: Clinicians have reported temporal associations between vaccine administration and onset of MS or other CNS demyelinating diseases. Yet, whether vaccines, particularly for hepatitis B (HepB) and human papilloma virus (HPV), can trigger MS or other CNS demyelinating diseases remains controversial.
DESIGN/METHODS: We conducted a case-control study from the membership of Kaiser Permanente Southern California (KPSC). Cases were identified through the KPSC Acquired Demyelinating Diseases (ADS) Cohort between 2008 and 2011. Five controls per case were matched on age, sex and zip code. Data were obtained from the complete electronic health record and analyzed using conditional logistic regression, adjusted for race/ethnicity, health care utilization, and infectious illnesses prior to symptom onset.
RESULTS: We identified 780 incident cases of CNS ADS and 3885 controls, of which 92 cases and 459 controls were women ages 9-26 years, the indicated age rage for HPV vaccination. There were no associations between hepatitis B vaccination (OR 1.12, 95% CI 0.72-1.73); HPV vaccination (OR 1.05 95% CI 0.62-1.78); or any vaccination (OR 1.03, 95% CI 0.86-1.22) and the risk of CNS ADS up to 3 years later. Vaccination of any type was associated with an increased risk of CNS ADS onset within the first 30 days after vaccination in younger (<50 years) individuals only (OR 2.32, 95%CI 1.18-4.57).
CONCLUSIONS: We found no longer-term association of vaccines with MS or other CNS demyelinating diseases, which argues against a causal association. The short-term increase in risk suggests vaccines may accelerate the transition from subclinical to overt autoimmunity in patients with existing disease. Our findings do not suggest a need for change in vaccine policy.
Study Supported by: Kaiser Permanente Direct Community Benefit Funds and NIH-NINDS, 1R01NS075308 PI: Langer-Gould)
Disclosure: Dr. Langer-Gould has received research support from Biogen Idec and Roche. Dr. Chen has nothing to disclose. Dr. Tartof has nothing to disclose. Dr. Chao has nothing to disclose. Dr. Tseng has nothing to disclose.

Current Opinion in Pediatrics
April 2014 – Volume 26 – Issue 2 pp: v-vi,137-264
http://journals.lww.com/co-pediatrics/pages/currenttoc.aspx
CURRENT OPINION Child and adolescent immunizations: selected review of recent US recommendations and literature
Kao, Carol M.; Schneyer, Rebecca J.; Bocchini, Joseph A. Jr.
Abstract
Purpose of review: To provide a clinically relevant summary of the latest research and recommendations regarding childhood and adolescent immunizations.
Recent findings: Childhood vaccination has dramatically reduced pediatric morbidity and mortality in the United States. Recent research on childhood and adolescent immunizations has focused on expanding the use of current vaccines for additional subpopulations as well as the development of new vaccines. In particular, data confirming the safety and immunogenicity of vaccines in various groups of children have shaped national guidelines. Furthermore, studies on vaccine uptake, cost-effectiveness, and impact of vaccination have reinforced the importance of adhering to these guidelines. More work needs to be done by providers and parents to increase vaccination coverage rates to better protect children and adolescents from these serious diseases. In this article, selected recent publications and recommendations on the following vaccines are reviewed: influenza, meningococcal conjugate, childhood and adolescent/adult formulations of diphtheria and tetanus toxoids and acellular pertussis, pneumococcal conjugate, and human papillomavirus.
Summary: Research on childhood and adolescent vaccinations continues to shape future guidelines. Through this work, we can learn how to optimize the protection of all children and adolescents against vaccine-preventable diseases.

Cell
Volume 157, Issue 2 April 10, 2014
http://www.cell.com/cell/current
Essay
Peering into the Crystal Ball: Influenza Pandemics and Vaccine Efficacy
Matthew S. Miller, Peter Palese
Volume 157, Issue 2, p294–299, 10 April 2014
DOI: http://dx.doi.org/10.1016/j.cell.2014.03.023
Summary
The looming threat of a new influenza virus pandemic has fueled ambitious efforts to devise more predictive parameters for assessing the risks associated with emergent virus strains. At the same time, a comprehensive understanding of critical factors that can accurately predict the outcome of vaccination is sorely needed in order to improve the effectiveness of influenza virus vaccines. Will new studies aimed at identifying adaptations required for virus transmissibility and systems-level analyses of influenza virus vaccine responses provide an improved framework for predictive models of viral adaptation and vaccine efficacy?