Nature Immunology
May 2014, Volume 15 No 5 pp 403-481
http://www.nature.com/ni/journal/v15/n5/index.html

Commentary
Vaccines against tropical parasitic diseases: a persisting answer to a persisting problem – pp403 – 405
David L Sacks
doi:10.1038/ni.2853
Live whole-organism vaccines against Plasmodium falciparum malaria and cutaneous leishmaniasis remain the most uniformly effective vaccines against human parasitic diseases. These vaccines are discussed in terms of the requirement for persisting antigen to generate and maintain a protective response.