Quadrivalent Human Papillomavirus Vaccine and the Risk of Venous Thromboembolism

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JAMA
July 9, 2014, Vol 312, No. 2
http://jama.jamanetwork.com/issue.aspx

Research Letter | July 9, 2014
Quadrivalent Human Papillomavirus Vaccine and the Risk of Venous Thromboembolism
Nikolai Madrid Scheller, MB1; Björn Pasternak, MD, PhD1; Henrik Svanström, MSc1; Anders Hviid, DrMedSci1
Author Affiliations
JAMA. 2014;312(2):187-188. doi:10.1001/jama.2014.2198.
A potential association between quadrivalent human papillomavirus (HPV) vaccination and venous thromboembolism (VTE) has been reported in 2 postlicensure safety studies.1,2 An analysis of the Vaccine Adverse Event Reporting System database found disproportionately high reporting of VTE following vaccination,1 and a study using the Vaccine Safety Datalink reported a doubling of VTE risk.2