JAMA
July 23/30, 2014, Vol 312, No. 4
http://jama.jamanetwork.com/issue.aspx

Viewpoint | July 23/30, 2014
An HIV Cure: Feasibility, Discovery, and Implementation
Anthony S. Fauci, MD1; Hilary D. Marston, MD, MPH1; Gregory K. Folkers, MS, MPH1
Author Affiliations
JAMA. 2014;312(4):335-336. doi:10.1001/jama.2014.4754
Initial text
The discovery and deployment of antiretroviral therapy (ART) for human immunodeficiency virus (HIV) infection is one of the most extraordinary achievements in recent biomedical history. Between 1996 and 2012, ART averted an estimated 6.6 million AIDS-related deaths worldwide.1 For HIV-infected individuals with access to ART, life expectancy at diagnosis now approximates that of uninfected individuals—a remarkable feat. These extraordinary successes, however, are tempered by the necessity of lifelong drug therapy. Many patients struggle with adherence in the face of competing priorities, both within the clinical context (comorbidities) and beyond (food insecurity, housing, substance abuse, and other challenges). The drugs can cause health issues in the form of cumulative toxicities. Nations and health systems struggle to find the resources needed to provide long-term therapy. The challenges of resistance and drug-drug interactions add considerable complexity to the provision of care….

Realization of an AIDS-Free Generation: Ensuring Sustainable Treatment for Children
Shirin Heidari, PhD; Lynne M. Mofenson, MD; Linda-Gail Bekker, MBChB, FCP, PhD

Maximizing Benefits of New Strategies to Prevent Mother-to-Child HIV Transmission Without Harming Existing Services
Benjamin H. Chi, MD, MSc; Harsha Thirumurthy, PhD; Jeffrey S. A. Stringer, MD
Editorials
Integrating HIV Prevention Into Practice
Bradley M. Mathers, MBChB, MD; David A. Cooper, MD, DSc

HIV/AIDS: Gaining Ground and Forging Forward
Jeanette M. Smith, MD

Special Communication
HIV Prevention in Clinical Care Settings: 2014 Recommendations of the International Antiviral Society–USA Panel
Jeanne M. Marrazzo, MD, MPH; Carlos del Rio, MD; David R. Holtgrave, PhD; Myron S. Cohen, MD; Seth C. Kalichman, PhD; Kenneth H. Mayer, MD; Julio S. G. Montaner, MD; Darrell P. Wheeler, PhD, MPH; Robert M. Grant, MD, MPH; Beatriz Grinsztejn, MD, PhD; N. Kumarasamy, MD, PhD; Steven Shoptaw, PhD; Rochelle P. Walensky, MD, MPH; Francois Dabis, MD, PhD; Jeremy Sugarman, MD, MPH; Constance A. Benson, MD

Antiretroviral Treatment of Adult HIV Infection: 2014 Recommendations of the International Antiviral Society–USA Panel
Huldrych F. Günthard, MD; Judith A. Aberg, MD; Joseph J. Eron, MD; Jennifer F. Hoy, MBBS, FRACP; Amalio Telenti, MD, PhD; Constance A. Benson, MD; David M. Burger, PharmD, PhD; Pedro Cahn, MD, PhD; Joel E. Gallant, MD, MPH; Marshall J. Glesby, MD, PhD; Peter Reiss, MD, PhD; Michael S. Saag, MD; David L. Thomas, MD, MPH; Donna M. Jacobsen, BS; Paul A. Volberding, MD

Research Letter
Trends in Diagnoses of HIV Infection in the United States, 2002-2011
Anna Satcher Johnson, MPH; H. Irene Hall, PhD; Xiaohong Hu, MS; Amy Lansky, PhD, MPH; David R. Holtgrave, PhD; Jonathan Mermin, MD, MPH