Vaccine
Volume 32, Issue 41, Pages 5259-5370 (15 September 2014)
http://www.sciencedirect.com/science/journal/0264410X/32/41

Global vaccine supply. The increasing role of manufacturers from middle income countries
Pages 5259-5265
Donald P. Francis, Yu-Ping Du, Alexander R. Precioso
Abstract
Hallmarks in the remarkable evolution of vaccines and their application include the eradication of smallpox, the development and delivery of the early childhood vaccines and the emergence of recombinant vaccines initiated by the hepatitis B vaccine. Now we enter a most exciting era as vaccines are increasingly produced and delivered in less developed countries. The results are dramatic decreases in childhood morbidity and mortality around the world.