From Google Scholar+ [to 13 December 2014]

From Google Scholar & other sources: Selected Journal Articles, Newsletters, Dissertations, Theses, Commentary

Frontiers in Microbiology
5:741
The case for a rational genome-based vaccine against malaria
Review ARTICLE
Carla Proietti1 and Denise Doolan1*
1QIMR Berghofer Medical Research Institute, Australia
doi: 10.3389/fmicb.2014.00741
Historically, vaccines have been designed to mimic the immunity induced by natural exposure to the target pathogen, but this approach has not been effective for any parasitic pathogens of humans or complex pathogens that cause chronic disease in humans, such as Plasmodium. Despite intense efforts by many laboratories around the world on different aspects of Plasmodium spp. molecular and cell biology, epidemiology and immunology, progress towards the goal of an effective malaria vaccine has been disappointing. The premise of rational vaccine design is to induce the desired immune response against the key pathogen antigens or epitopes targeted by protective immune responses. We advocate that development of an optimally efficacious malaria vaccine will need to improve on nature, and that this can be accomplished by rational vaccine design facilitated by mining genomic, proteomic and transcriptomic datasets in the context of relevant biological function. In our opinion, modern genome-based rational vaccine design offers enormous potential above and beyond that of whole-organism vaccines approaches established over 200 years ago where immunity is likely suboptimal due to the many genetic and immunological host-parasite adaptations evolved to allow the Plasmodium parasite to coexist in the human host, and which are associated with logistic and regulatory hurdles for production and delivery.

Journal of Racial and Ethnic Health Disparities
December 2014
http://link.springer.com/journal/40615
Racial/Ethnic Disparities in HPV Vaccine Uptake Among a Sample of College Women
Chukwuemeka Okafor, Xingdi Hu, Robert L Cook
Abstract
Objective
The aim of this study is to determine the association between racial/ethnic status and uptake and completion of the HPV vaccine series in college women.
Methods
Participants were recruited from a large university in North Central Florida. Young women between 18 and 26 years of age who were currently enrolled in a college course comprised the study sample. Participants completed an anonymous online survey that assessed sociodemographic characteristics, sexual behaviors, gynecological healthcare utilization, and perception of risk to HPV-associated diseases. Multivariable analysis was conducted to determine the relationship between racial/ethnic status and HPV vaccination status.
Results
Of the 835 with complete data (51.0 % white, 16.5 % black, 13.8 % Hispanic, 8.3 % Asian, and 9.9 % other), 53 % had initiated (receipt of at least one dose) the three-dose HPV vaccine series. Of those who initiated, 70 % indicated that they had completed all three doses. In adjusted analysis, blacks were significantly less likely to report initiation [adjusted prevalence ratio (aPR) = 0.78; 95 % confidence interval (CI), 0.63, 0.97] and completion (aPR = 0.64; 95 % CI: 0.48, 0.84) of the three dose HPV vaccine as compared to whites. Although completion rates were lower in all other racial/ethnic groups as compared to whites, these rates did not reach statistical significance.
Conclusions
These findings are consistent with research from other types of settings and demonstrate lower initiation and completion rates of HPV vaccine among black women attending college as compared to their white counterparts. Additional research is needed to understand why black college women have low initiation and completion rates.

Special Focus Newsletters
MVI Update – PATH Malaria Vaccine Initiative
December 2014
:: Greetings from the director
:: Japan’s GHIT Fund announces award to MVI
:: Biting back? Immunize mosquitoes
:: RTS,S submitted to European regulatory authority
:: Direct Membrane-Feeding Assay Workshop
:: Interview with Rick King, MVI R&D Director