Vaccine
Volume 33, Issue 17, Pages 1999-2096 (21 April 2015)
http://www.sciencedirect.com/science/journal/0264410X/33/17

Alternative delivery of a thermostable inactivated polio vaccine
Original Research Article
Pages 2030-2037
Heleen Kraan, Ivo Ploemen, Gijsbert van de Wijdeven, Ivo Que, Clemens Löwik, Gideon Kersten, Jean-Pierre Amorij
Highlights
– Potential of Bioneedle technology for inactivated polio vaccine (IPV) was evaluated.
– IPV in Bioneedles is more resistant to elevated temperatures than liquid IPV.
– Comparable immunogenicity of IPV-Bioneedle and liquid IPV after booster vaccination.
– Similar kinetics at administration site for Bioneedle compared to liquid injection.
– LPS-derivate PagL is potent adjuvant for liquid IPV, not for IPV-Bioneedles

Original Research Article
Pages 2030-2037
Heleen Kraan, Ivo Ploemen, Gijsbert van de Wijdeven, Ivo Que, Clemens Löwik, Gideon Kersten, Jean-Pierre Amorij
Highlights
– Potential of Bioneedle technology for inactivated polio vaccine (IPV) was evaluated.
– IPV in Bioneedles is more resistant to elevated temperatures than liquid IPV.
– Comparable immunogenicity of IPV-Bioneedle and liquid IPV after booster vaccination.
– Similar kinetics at administration site for Bioneedle compared to liquid injection.
– LPS-derivate PagL is potent adjuvant for liquid IPV, not for IPV-Bioneedles