JAMA
June 23/30, 2015, Vol 313, No. 24
http://jama.jamanetwork.com/issue.aspx

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Viewpoint | June 23/30, 2015 Scientific Discovery and the Future of Medicine
Broadly Neutralizing Antibodies and the Development of Vaccines
Barton F. Haynes, MD1,2,3; Todd Bradley, PhD1,3
Author Affiliations
JAMA. 2015;313(24):2419-2420. doi:10.1001/jama.2015.2427.
[Excerpt]
This Viewpoint discusses the importance and progress of neutralizing human immunodeficiency virus through efforts to induce broadly reactive neutralizing antibodies.
Human immunodeficiency virus (HIV) infects 2.5 million people worldwide and accounts for more than 1 million deaths every year. Thus, an HIV vaccine is desperately needed. One roadblock to development of an effective HIV vaccine is the extraordinary ability of HIV to mutate and evolve into myriad quasi-species. Therefore, a key goal in developing a successful HIV vaccine is the induction of antibodies that can recognize and neutralize the majority of HIV quasi-species, called broadly reactive neutralizing antibodies (bnAbs). The search for an HIV vaccine has led to a greater understanding of bnAbs…