Clinical Infectious Diseases (CID)
Volume 61 Issue 4 August 15, 2015
http://cid.oxfordjournals.org/content/current

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Clinical Features of Patients With Ebola Virus Disease in Sierra Leone
Enqiang Qin, Jingfeng Bi, Min Zhao, Ye Wang, Tongsheng Guo, Tao Yan, Zhiwei Li, Juan Sun,
Jieli Zhang, Suhong Chen, Yao Wu, Jin Li, and Yanwei Zhong
Clin Infect Dis. (2015) 61 (4): 491-495 doi:10.1093/cid/civ319
The mortality of patients with Ebola virus disease (EVD) was closely associated with age and duration from symptom onset to clinic presentation. Patients with EVD did not necessarily have fever. Early diagnosis and timely symptomatic treatment are important.

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The Use of TKM-100802 and Convalescent Plasma in 2 Patients With Ebola Virus Disease in the United States
Colleen S. Kraft1,2,a, Angela L. Hewlett3,a, Scott Koepsell4, Anne M. Winkler1, Christopher J. Kratochvil5, LuAnn Larson6, Jay B. Varkey2, Aneesh K. Mehta2, G. Marshall Lyon III2, Rachel J. Friedman-Moraco2, Vincent C. Marconi2, Charles E. Hill1, James N. Sullivan7, Daniel W. Johnson7, Steven J. Lisco7, Mark J. Mulligan2, Timothy M. Uyeki8, Anita K. McElroy8, Tara Sealy8, Shelley Campbell8, Christina Spiropoulou8, Ute Ströher8, Ian Crozier9, Richard Sacra10,
Michael J. Connor Jr11,12, Viranuj Sueblinvong11, Harold A. Franch12, Philip W. Smith3, and
Bruce S. Ribner2 for the Nebraska Biocontainment Unit and the Emory Serious Communicable Diseases Unitb
Abstract
Background.
The current West Africa Ebola virus disease (EVD) outbreak has resulted in multiple individuals being medically evacuated to other countries for clinical management.
Methods.
We report two patients who were transported from West Africa to the United States for treatment of EVD. Both patients received aggressive supportive care measures, as well as an investigational therapeutic (TKM-100802) and convalescent plasma.
Results.
While one patient experienced critical illness with multi-organ failure requiring mechanical ventilation and renal replacement therapy, both patients recovered without serious long-term sequelae to date.
Conclusions.
It is unclear what role the experimental drug and convalescent plasma had in the recovery of these patients. Prospective clinical trials are needed to delineate the role of investigational therapies in the care of patients with EVD.