Evaluating the impact of a national rotavirus vaccine programme on circulating strain types and identifying possible vaccine failures

Journal of Clinical Virology
September 2015 Volume 70, Supplement 1, S1-S132
http://www.journalofclinicalvirology.com/current?page=3

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Abstracts of the 18th Annual Meeting of European Society for Clinical Virology, 9th–12th September 2015, Edinburgh
Evaluating the impact of a national rotavirus vaccine programme on circulating strain types and identifying possible vaccine failures
A. Smith-Palmer, H. Murdoch, A. Hunt, I. Mukhopadhya, G. Hold, C. Cameron
Background: Rotavirus is a leading cause of gastroenteritis in children worldwide. In Scotland, most children will have had at least one rotavirus infection by age five years, with a number requiring hospitalisation for dehydration. To date at least 19 G and 27 P genotypes have been characterised in human rotaviruses. However, five strains are commonly detected worldwide namely G1P[8], G2P[4],G3P[8], G4P[8] and G9P[8]. In July 2013 Rotarix®, a live attenuated oral vaccine was introduced into the routine infant immunisation schedule with doses at two and three months.