Current Opinion in Biotechnology
Volume 42, December 2016, Pages 24–29

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Pharmaceutical biotechnology • Chemical biotechnology
Enhancing vaccine effectiveness with delivery technology
M Beitelshees, Y Li, BA Pfeifer
Highlights
:: Vaccine potency can be influenced by antigen delivery technology.
:: Chemical vectors covered include microneedle devices and liposomes.
:: Biological vectors covered include attenuated bacterial hosts.
:: A diverse set of properties and tools enable vaccine delivery vector impact.

Vaccines stand as a very powerful means of disease prevention and treatment. Fundamental to the success of vaccination is the efficient delivery of antigenic cargo needed to trigger an effective immune response. In this article, we will review recent advances in delivery technology with a focus on devices designed to optimally maximize responses to antigen cargo. Included with the review is an overview of traditional vaccine applications and how these approaches can benefit by well-designed delivery methods