IVI [to 19 March 2016]
http://www.ivi.org/web/www/home

.
16 March 2916
The International Vaccine Institute (IVI) is pleased to announce the publication of the “Typhoid Fever Surveillance in Africa Program (TSAP)” supplement of Clinical Infectious Diseases.
The seminal publication contains 15 original articles that report significant research findings from the TSAP Program. TSAP was established by IVI in 2009 to fill the data void concerning invasive Salmonella disease in sub-Saharan Africa, and to estimate the burden of bloodstream infections caused by the key pathogen, Salmonella enterica serovar Typhi. IVI, in collaboration with various partners, conducted standardized disease surveillance and other studies in a network of 13 sentinel sites in 10 sub-Saharan African countries. The supplement is the culmination of four years of a landmark study that aimed to definitively determine the burden of invasive Salmonella disease in Africa.

The supplement is open-access and can be viewed at: http://cid.oxfordjournals.org/content/62/suppl_1.toc

.Major findings:
:: High incidences of disease by Salmonella Typhi and invasive non-typhoidal Salmonella (iNTS) in children :: High incidences of typhoid fever in both rural and urban populations
:: Positive correlation between iNTS disease and malaria endemicity
:: Prevalence of resistance to first-line antimicrobial agents seen in both S. Typhi and iNTS isolates in some locations
:: Evidence of NTS excretion in stool may indicate possible disease transmission
:: Patients with fever who sought health care were assessed across all 13 sites; pivotal for disease burden surveillance and incidence analysis