Nature
Volume 533 Number 7601 pp7-138 5 May 2016
http://www.nature.com/nature/current_issue.html

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Comment
Policy: Security spending must cover disease outbreaks
Tadataka Yamada, V. Ayano Ogawa and Maria Freire call for research and development funding and coordination to counter global infectious-disease threats.

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Letters
Unique human immune signature of Ebola virus disease in Guinea
Paula Ruibal, Lisa Oestereich, Anja Lüdtke, Beate Becker-Ziaja, David M. Wozniak+ et al.
Fatal Ebola virus disease is characterized by a high proportion of CD4+ and CD8+ T cells expressing the inhibitory molecules CTLA-4 and PD-1, correlating with high virus load; individuals who survive the infection exhibit lower expression of these inhibitory molecules and generate Ebola-specific CD8+ T cells, suggesting that dysregulation of the T cell response is a key component of Ebola virus disease pathophysiology.