Science Translational Medicine
29 June 2016 Vol 8, Issue 345
http://stm.sciencemag.org/

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Perspective
Multicriteria decision analysis and core values for enhancing vaccine-related decision-making
By Michèle A. Barocchi, Steve Black, Rino Rappuoli
Science Translational Medicine29 Jun 2016 : 345ps14
Abstract
Vaccines have the potential to transform the health of all individuals and to reduce the health inequality between rich and poor countries. However, to achieve these goals, it is no longer sufficient to prioritize vaccine development using cost-effectiveness as the sole indicator. During a symposium entitled “Mission Grand Convergence—The Role of Vaccines,” held in Siena, Italy, in July 2015, key stakeholders agreed that the prioritization of vaccine development and deployment must use multicriteria decision-making based on the following core concepts: (i) mortality and severity of the disease, (ii) vaccine safety considerations, and (iii) economic evaluation that captures the full benefits of vaccination.