New England Journal of Medicine
July 7, 2016 Vol. 375 No. 1
http://www.nejm.org/toc/nejm/medical-journal

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Perspective
Zika and the Risk of Microcephaly
M.A. Johansson, L. Mier-y-Teran-Romero, J. Reefhuis, S.M. Gilboa, and S.L. Hills

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Review Article
The Changing Face of Clinical Trials: Adaptive Designs for Clinical Trials
D.L. Bhatt and C. Mehta
Investigators use adaptive trial designs to alter basic features of an ongoing trial. This approach obtains the most information possible in an unbiased way while putting the fewest patients at risk. In this review, the authors discuss selected issues in adaptive design.