New England Journal of Medicine
April 5, 2018   Vol. 378 No. 14
http://www.nejm.org/toc/nejm/medical-journal

Review Article
The Key Role of Epigenetics in Human Disease Prevention and Mitigation
Andrew P. Feinberg, M.D., M.P.H.
Epigenetics is the regulation of gene expression through alterations in DNA or associated factors (other than the DNA sequence). These factors control the diverse manifestations of diseases. Insights into epigenetic modification may lead to new therapies for common diseases.