Nature Genetics
Volume 51 Issue 12, December 2019
https://www.nature.com/ng/volumes/51/issues/12

Mapping the regulatory wiring of the genome
The human genome encodes millions of enhancers (tangled balls) that quantitatively tune the expression of 21,000 genes (arrows). The regulatory wiring connecting enhancers to their target genes has remained elusive. In this issue, Fulco, Nasser and colleagues develop new experimental and computational approaches to map this complex wiring, and demonstrate their utility in interpreting the functions of genetic variants associated with human diseases.