Nature
Volume 578 Issue 7794, 13 February 2020
http://www.nature.com/nature/current_issue.html

Review Article | 12 February 2020
The promise and challenge of therapeutic genome editing
The scientific, technical and ethical aspects of using CRISPR technology for therapeutic applications in humans are discussed, highlighting both opportunities and challenges of this technology to treat, cure and prevent genetic disease.
Jennifer A. Doudna