JAMA
March 3, 2020, Vol 323, No. 9, Pages 809-902
http://jama.jamanetwork.com/issue.aspx

Estimated Research and Development Investment Needed to Bring a New Medicine to Market, 2009-2018
Olivier J. Wouters, PhD; Martin McKee, MD, DSc; Jeroen Luyten, PhD
JAMA. 2020;323(9):844-853. doi:10.1001/jama.2020.1166
This study uses publicly available data to analyze research and development spending to win FDA approval and bring new drugs to market between 2009 and 2018.