Supporting a data-driven approach to regulatory intelligence

Nature Reviews Drug Discovery
Volume 20 Issue 3, March 2021
https://www.nature.com/nrd/volumes/20/issues/3

 

Comment | 28 May 2020
Supporting a data-driven approach to regulatory intelligence
Drug developers are increasingly applying data-driven analysis of the actions of regulatory agencies to gain insights into their expectations and applications of regulatory policy, but such strategies can be limited by the availability and quality of regulatory datasets. Here, we discuss how establishing a single, robust, accessible database of FDA regulatory actions could help address this limitation.
Andrew S. Robertson, Alexis Reisin Miller & Felipe Dolz

Improving Influenza Vaccination in Children With Comorbidities: A Systematic Review

Pediatrics
Vol. 147, Issue 3 1 Mar 2021
https://pediatrics.aappublications.org/

 

Review Articles
Improving Influenza Vaccination in Children With Comorbidities: A Systematic Review
Daniel A. Norman, Rosanne Barnes, Rebecca Pavlos, Mejbah Bhuiyan, Kefyalew Addis Alene, Margie Danchin, Holly Seale, Hannah C. Moore, Christopher C. Blyth
Pediatrics, Mar 2021, 147 (3) e20201433

Allocating epidemic response teams and vaccine deliveries by drone in generic network structures, according to expected prevented exposures

PLoS One
http://www.plosone.org/
[Accessed 6 Mar 2021]

 

Allocating epidemic response teams and vaccine deliveries by drone in generic network structures, according to expected prevented exposures
Dean Matter, Linke Potgieter
Research Article | published 05 Mar 2021 PLOS ONE
https://doi.org/10.1371/journal.pone.0248053

The exposure risk to COVID-19 in most affected countries: A vulnerability assessment model

PLoS One
http://www.plosone.org/
[Accessed 6 Mar 2021]

 

The exposure risk to COVID-19 in most affected countries: A vulnerability assessment model
Adriana Nascimento Santos Cartaxo, Francisco Iran Cartaxo Barbosa, Paulo Henrique de Souza Bermejo, Marina Figueiredo Moreira, David Nadler Prata
Research Article | published 04 Mar 2021 PLOS ONE
https://doi.org/10.1371/journal.pone.0248075

Oral health care professionals recommending and administering the HPV vaccine: Understanding the strengths and assessing the barriers

PLoS One
http://www.plosone.org/
[Accessed 6 Mar 2021]

 

Oral health care professionals recommending and administering the HPV vaccine: Understanding the strengths and assessing the barriers
Denise Guadiana, Nolan M. Kavanagh, Cristiane H. Squarize
Research Article | published 04 Mar 2021 PLOS ONE
https://doi.org/10.1371/journal.pone.0248047

Trust and Risk Perception: A Critical Review of the Literature

Risk Analysis
Volume 41, Issue 3 Pages: 407-557 March 2021
https://onlinelibrary.wiley.com/toc/15396924/current

 

Special Issue:40 Years of Social Sciences in Risk Research Reconsidered
Original Research Articles
Trust and Risk Perception: A Critical Review of the Literature
Michael Siegrist
Pages: 480-490
First Published: 02 May 2019
Abstract
Many studies in the field of risk perception and acceptance of hazards include trust as an explanatory variable. Despite this, the importance of trust has often been questioned. The relevant issue is not only whether trust is crucial but also the form of trust that people rely on in a given situation. In this review, I discuss various trust models and the relationship between trust and affect heuristics. I conclude that the importance of trust varies by hazard and respondent group. Most of the studies use surveys that provide limited information about causality. Future research should focus more on experiments that test whether trust is a consequence of people’s attitudes or influences their attitudes toward a technology. Furthermore, there is a need for a better understanding about the factors that determine which heuristics people rely on when evaluating hazards.

Editorial Science’s new frontier

Science
05 March 2021 Vol 371, Issue 6533
http://www.sciencemag.org/current.dtl

 

Editorial
Science’s new frontier
By Aaron F. Mertz, Abhilash Mishra
Science05 Mar 2021 : 96
Summary
The year 2020 saw a reusable rocket launch two astronauts into space, multiple COVID-19 vaccines developed in record time, and a robot that could write a persuasive op-ed. In the United States, the year also saw public distrust of science contribute to the worst health crisis in modern history. This contrast highlights a sharp dichotomy in the role of science in American public life: breathtaking discovery and innovation alongside growing distrust of scientific evidence and recommendations. How can the country reconcile this dissociation?

Human embryo research beyond the primitive streak

Science
05 March 2021 Vol 371, Issue 6533
http://www.sciencemag.org/current.dtl

 

Policy Forum
Human embryo research beyond the primitive streak
By Insoo Hyun, Annelien L. Bredenoord, James Briscoe, Sigal Klipstein, Tao Tan
Science05 Mar 2021 : 998-1000 Restricted Access
It is time to revisit the “14-day limit”
Summary
Since the first successful birth resulting from in vitro fertilization (IVF) in the late 1970s, human embryo research has been subject to limits of time and developmental benchmarks. National guidelines, laws, and international norms have prohibited scientists from culturing embryos for research beyond 14 consecutive days, or beyond the appearance of a structure called the “primitive streak,” which defines the beginning of the formation of the principal tissues of the body and the end of the period when an embryo can divide into identical twins (1). At the time this limit was put in place 40 years ago, there were no methods to culture embryos in a dish for anywhere close to 14 days. But research since 2016 (2, 3) shows that it is likely possible to culture human research embryos past the 2-week limit and suggests that doing so will yield scientific insights that could prove important for human health and fertility (4). We thus urge policy-makers and the International Society for Stem Cell Research (ISSCR), which will soon release updated guidelines for stem cell and embryo research, to consider a cautious, stepwise approach to scientific exploration beyond the 14-day limit.

Infectious diseases and social distancing in nature

Science
05 March 2021 Vol 371, Issue 6533
http://www.sciencemag.org/current.dtl

 

Review
Infectious diseases and social distancing in nature
By Sebastian Stockmaier, Nathalie Stroeymeyt, Eric C. Shattuck, Dana M. Hawley, Lauren Ancel Meyers, Daniel I. Bolnick
Science05 Mar 2021
Nature’s “responsible” response to disease
With the emergence of the COVID-19 pandemic, there have been global calls for the implementation of “social distancing” to control transmission. Throughout the world, some have resisted this requirement with the unfounded argument that it is unnecessary or ineffective. Social distancing, however, is a natural consequence of disease across animals, both human and nonhuman. Stockmaier et al. reviewed responses to disease across animal taxa and reveal how these responses naturally limit disease transmission. Understanding such natural responses and their impacts on pathogenic transmission provides epidemiological insight into our own responses to pandemic challenges.
Abstract
Spread of contagious pathogens critically depends on the number and types of contacts between infectious and susceptible hosts. Changes in social behavior by susceptible, exposed, or sick individuals thus have far-reaching downstream consequences for infectious disease spread. Although “social distancing” is now an all too familiar strategy for managing COVID-19, nonhuman animals also exhibit pathogen-induced changes in social interactions. Here, we synthesize the effects of infectious pathogens on social interactions in animals (including humans), review what is known about underlying mechanisms, and consider implications for evolution and epidemiology.

Improving COVID-19 vaccine acceptance: Including insights from human decision-making under conditions of uncertainty and human-centered design

Vaccine
Volume 39, Issue 11 Pages 1547-1666 (12 March 2021)
https://www.sciencedirect.com/journal/vaccine/vol/39/issue/11

 

Editorial Full text access
Improving COVID-19 vaccine acceptance: Including insights from human decision-making under conditions of uncertainty and human-centered design
Caroline M. Poland, Allison K.S. Matthews, Gregory A. Poland
Pages 1547-1550

Situational assessment of adult vaccine preventable disease and the potential for immunization advocacy and policy in low- and middle-income countries

Vaccine
Volume 39, Issue 11 Pages 1547-1666 (12 March 2021)
https://www.sciencedirect.com/journal/vaccine/vol/39/issue/11

Review article Open access
Situational assessment of adult vaccine preventable disease and the potential for immunization advocacy and policy in low- and middle-income countries
Molly Sauer, Prarthana Vasudevan, Ankita Meghani, Karuna Luthra, … Lois Privor-Dumm
Pages 1556-1564

Acceptability of a COVID-19 Vaccine among the Saudi Population

Vaccines — Open Access Journal
http://www.mdpi.com/journal/vaccines
(Accessed 6 Mar 2021)

 

Open Access Article
Acceptability of a COVID-19 Vaccine among the Saudi Population
by Eman Ibrahim Alfageeh et al.
Vaccines 2021, 9(3), 226; https://doi.org/10.3390/vaccines9030226 – 05 Mar 2021
Abstract
To investigate the associated factors underlying vaccination intentions for Coronavirus Disease 2019 (COVID-19), an online cross-sectional survey was conducted among adults 18 years or over in the Kingdom of Saudi Arabia. Data were collected between 8 and 14 December 2020. A logistic regression […] R

Attitude and Behaviors towards SARS-CoV-2 Vaccination among Healthcare Workers: A Cross-Sectional Study from Poland

Vaccines — Open Access Journal
http://www.mdpi.com/journal/vaccines
(Accessed 6 Mar 2021)

 

Open Access Article
Attitude and Behaviors towards SARS-CoV-2 Vaccination among Healthcare Workers: A Cross-Sectional Study from Poland
by Bartosz Szmyd et al
Vaccines 2021, 9(3), 218; https://doi.org/10.3390/vaccines9030218 – 04 Mar 2021
Abstract
Healthcare workers are particularly exposed to biological risk during their daily occupational activities. Nowadays, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become one of the most widespread infectious agents. In the current study, we performed a survey on the attitude and behavior […]

Acceptance of a COVID-19 Vaccine in Japan during the COVID-19 Pandemic

Vaccines — Open Access Journal
http://www.mdpi.com/journal/vaccines
(Accessed 6 Mar 2021)

 

Open Access Article
Acceptance of a COVID-19 Vaccine in Japan during the COVID-19 Pandemic
by Masaki Machida et al.
Vaccines 2021, 9(3), 210; https://doi.org/10.3390/vaccines9030210 – 03 Mar 2021
Abstract
Vaccination could be a key protective measure against coronavirus disease 2019 (COVID-19), and it is important to understand the acceptability of the COVID-19 vaccine among the general public. However, there is no study on the acceptance of a COVID-19 vaccine in Japan. Therefore, […]

COVID-19 Vaccine Acceptance among an Online Sample of Sexual and Gender Minority Men and Transgender Women

Vaccines — Open Access Journal
http://www.mdpi.com/journal/vaccines
(Accessed 6 Mar 2021)

 

Open Access Article
COVID-19 Vaccine Acceptance among an Online Sample of Sexual and Gender Minority Men and Transgender Women
by Daniel Teixeira da Silva et al
Vaccines 2021, 9(3), 204; https://doi.org/10.3390/vaccines9030204 – 01 Mar 2021
Abstract
Sexual and gender minority (SGM) populations are particularly vulnerable to poor COVID-19 outcomes and are more likely to experience stigma and medical mistrust that may impact COVID-19 vaccine acceptance. This study examined the prevalence of COVID testing and diagnosis and assessed COVID-19 vaccine […]

Media/Policy Watch

Media/Policy Watch
This watch section is intended to alert readers to substantive news, analysis and opinion from the general media and selected think tanks and similar organizations on vaccines, immunization, global public health and related themes. Media Watch is not intended to be exhaustive, but indicative of themes and issues CVEP is actively tracking. This section will grow from an initial base of newspapers, magazines and blog sources, and is segregated from Journal Watch above which scans the peer-reviewed journal ecology.
We acknowledge the Western/Northern bias in this initial selection of titles and invite suggestions for expanded coverage. We are conservative in our outlook in adding news sources which largely report on primary content we are already covering above. Many electronic media sources have tiered, fee-based subscription models for access. We will provide full-text where content is published without restriction, but most publications require registration and some subscription level.

 

The Atlantic
http://www.theatlantic.com/magazine/
Accessed 6 Mar 2021
Ideas
America’s Legalistic Culture Is About to Become a Problem
The vaccine rollout will create new clashes between conflicting rights.
March 4, 2021
Jamal Greene, Professor at Columbia Law School
As vaccine production and distribution accelerate, a new set of challenges around what Americans can and should demand of one another is emerging. And we’re not ready for them. The public has been told for the past year that we need to mask up, physically distance, and lock down for the greater good. Now that vaccines are here, does that same greater good mean that society can discriminate against the unvaccinated? Do Americans have a right not to get vaccinated? If so, how far does that right go?

 

BBC
http://www.bbc.co.uk/
Accessed 6 Mar 2021
[No new, unique, relevant content]

 

The Economist
http://www.economist.com/
Accessed 6 Mar 2021
Bartleby
How companies should handle vaccines
Balancing the rights of stakeholders
THE PANDEMIC is throwing up a new set of ethical issues for businesses. The premise of “stakeholder capitalism” is not just that firms should consider the interests of employees and customers, as well as shareholders. It is that, by doing so, everyone gains; shareholders will prosper if workers and customers are treated decently. But the pandemic may put different groups at odds. For example, customers may want companies to insist that all employees are vaccinated, while not wanting the same rule to apply to themselves.
Mar 6th 2021

 

Financial Times
https://www.ft.com/
Accessed 6 Mar 2021
Covid-19 vaccines
EU turns to US in scramble for Oxford/AstraZeneca vaccine
Move is part of bloc’s effort to boost faltering immunisation programme
Sam Fleming and Michael Peel in Brussels, and Kiran Stacey in Washington
March 6
The EU will urge the US to permit the export of millions of doses of AstraZeneca’s Covid-19 vaccine to Europe as Brussels scrambles to bridge supply shortfalls that have hobbled its inoculation drive.
The European Commission plans to raise the matter in forthcoming transatlantic discussions aimed at boosting collaboration on the fight against Covid-19, EU officials said.
The EU also wants Washington to ensure the free flow of shipments of crucial vaccine ingredients needed in European production, including for groundbreaking mRNA technology vaccines…

Coronavirus:
Germany urges EU coordination after Italy blocks vaccine shipment
Germany has urged caution on vaccines, after France backed Italy’s decision to block a shipment of jabs to Australia.
The German health minister on Friday said that such unilateral steps were unhelpful and could disrupt supply chains, adding that Europe should act in a more coordinated way when it comes to such export restrictions.
March 5, 2021

Bottom of Form

 

Forbes
http://www.forbes.com/
Accessed 6 Mar 2021
Mar 6, 2021
Europe’s Vaccine Struggle Will Change Its Politics
France and much of Europe has fallen behind with vaccinating its citizens, this may lead to political stress down the line and raises questions as to what countries are ready for the post COVID world.
By Mike O’Sullivan Senior Contributor

Mar 5, 2021
How Pfizer’s Head Of Vaccine Development Made Covid-19 Vaccine In Record Time And Led A Large Team
Kathrin Jansen has made waves in healthcare having led the development of Gardasil, now the Covid-19 vaccine and others. She leads with strength, organization and often, creativity and gut instincts. During the pandemic she led hundreds of people on this mission to develop an effective vaccine.
By Monica Haider Contributor

Mar 5, 2021
Fauci Says Military Who Refuse Covid-19 Vaccine Are ‘Part Of The Problem’ After High Rate Of Service Members Refuse Jab
Pentagon officials have said one in three military troops are refusing to take the optional Covid-19 shot.
By Robert Hart Forbes Staff

 

Foreign Affairs
http://www.foreignaffairs.com/
Accessed 6 Mar 2021
[No new, unique, relevant content]

 

Foreign Policy
http://foreignpolicy.com/
Accessed 6 Mar 2021
Argument
To Democratize Vaccine Access, Democratize Production
U.S. and European COVID-19 shots aren’t enough. It is time to tap into Africa, Asia, and Latin America’s enormous production capacity.
By Matthew M. Kavanagh, Mara Pillinger, Renu Singh, Katherine Ginsbach

 

The Guardian
http://www.guardiannews.com/
Accessed 6 Mar 2021
[No new, unique, relevant content]

 

New Yorker
http://www.newyorker.com/
Accessed 6 Mar 2021
Annals of Populism
The Vaccine Resisters
Why do so many people say that they won’t be immunized against COVID-19?
By Benjamin Wallace-Wells
March 5, 2021

 

New York Times
http://www.nytimes.com/
Accessed 6 Mar 2021
The Interpreter
Vaccine Passports, Covid’s Next Political Flash Point
A world divided between the vaccinated and unvaccinated promises relief for economies and families, but the ethical and practical risks are high.
March 2, 2021

 

Washington Post
https://www.washingtonpost.com/
Accessed 6 Mar 2021
Tibetan spiritual leader Dalai Lama gets vaccine shot
Associated Press · Mar 6, 2021

After days of halting statements about vaccine morality, multiple Catholic leaders call the shots urgent, important
Michelle Boorstein · Religion · Mar 5, 2021

WHO head pushes for waiver of some intellectual property rights for coronavirus vaccines, in bid to broaden access
Miriam Berger · World · Mar 5, 2021

France backs Italy in vaccine ban as EU defends mechanism
BRUSSELS — Europe’s vaccine solidarity got a boost on Friday after France said it could emulate Italy’s move to block coronavirus vaccine exports outside the European Union if that’s what is needed to enforce the bloc’s own contracts with drugs manufacturers.·
Mar 5, 2021

Think Tanks et al

Think Tanks et al

Brookings
http://www.brookings.edu/
Accessed 6 Mar 2021
Coronavirus (COVID-19)
One year in, COVID-19’s uneven spread across the US continues
William H. Frey
Friday, March 5, 2021

FixGov
Getting the COVID-19 vaccine: Progress, and equity questions for the next phase
Elaine Kamarck and William A. Galston
Thursday, March 4, 2021

Coronavirus (COVID-19)
Examining and addressing COVID-19 racial disparities in Detroit
Rashawn Ray, Jane Fran Morgan, Lydia Wileden, Samantha Elizondo, and Destiny Wiley-Yancy
Tuesday, March 2, 2021

Center for Global Development [to 6 Mar 2021]
http://www.cgdev.org/page/press-center
Publication
Equity and Scale in Global Immunization: New Evidence from Nigeria on Cash Transfers for Vaccination
Event
3/10/21
Even prior to COVID-19, full immunization for age was vastly unequal in large middle-income countries like Nigeria. As the COVID-19 crisis deepens, routine immunization has plummeted, and world leaders are seeking ways to regain ground and trust, even while considering how to roll out a COVID-19 vaccine.

Global Trends in 2021: How COVID-19 Is Transforming International Development
Publication
3/2/21
In this note, we explore some of the changes and trends in development agency strategic direction brought about by the pandemic, as well as fundamental challenges that bilateral development agencies will need to address in the years to come.

Chatham House [to 6 Mar 2021]
https://www.chathamhouse.org/
Accessed 6 Mar 2021
[No new digest content identified]

 

CSIS
https://www.csis.org/
Accessed 6 Mar 2021
Upcoming Event
A Conversation with Dr. Anthony Fauci and Professor Paul Kelly
March 9, 2021

Transcript
A Global Approach to COVID-19 Vaccination
March 4, 2021

 

Kaiser Family Foundation
https://www.kff.org/search/?post_type=press-release
Accessed 6 Mar 2021
March 4, 2021 News Release
THE CONVERSATION: Between Us, About Us, A New Campaign By Black Health Care Workers for Black People about the COVID-19 Vaccines
March 4, 2021 – THE CONVERSATION: Between Us, About Us. is a new campaign to provide Black communities with credible information about the COVID-19 vaccines co-developed by KFF (Kaiser Family Foundation) and the Black Coalition Against COVID. Black doctors, nurses and researchers dispel misinformation and provide accessible facts in 50…

March 3, 2021 News Release
KFF Tracking Poll: More Than a Third of Americans Say They’ve Struggled to Pay Living Expenses Since December; 6 in 10 Families Hit by COVID Have Lost A Job or Income
Majorities Favor Provisions to Expand Marketplace Tax Credits and Encourage States to Expand Medicaid As Congress considers an additional $1.9 trillion COVID-19 relief plan, more than a third (37%) of Americans say that someone in their household has had trouble paying basic living expenses over the past three months, the…

March 1, 2021 News Release
Many Nonelderly People With Disabilities Face COVID-19 Risks Similar to Those of the Elderly in Nursing Homes, But Do Not Have Equal Footing When it Comes to Vaccine Priority
While the toll of COVID-19 on nursing home residents has been well documented, less noticed has been the experience of nonelderly people with disabilities who rely on long-term care services and supports outside of nursing homes. In many ways the two groups face similar health risks from the virus, but…

March 1, 2021 News Release
Analysis: Spending on Health Care Would Drop by an Estimated $352 Billion in 2021 if Private Insurance Used Medicare Rates to Reimburse Hospitals and Other Health Care Providers
Total health care spending for people with private health insurance would be an estimated $352 billion lower in 2021 if private insurers used Medicare rates to pay hospitals and other health care providers, rather than the substantially higher rates they currently pay, a new KFF analysis finds. That would represent…

Urban Institute [to 6 Mar 2021]
https://www.urban.org/publications
Publications
Reforming Long-Term Care with Lessons from the COVID-19 Pandemic
In October 2020, the Urban Institute hosted a roundtable of leading experts to discuss how the US cares for older adults in the wake of the COVID-19 pandemic. Participants highlighted key areas for reform and identified potential improvements. These included redesigning Medicaid; creating a strong foundation for home- and community-based services; integrating medical care and long-term services and
Howard Gleckman, Melissa M. Favreault
March 2, 2021
Brief

World Economic Forum [to 6 Mar 2021]
https://agenda.weforum.org/news/
Media
[No new relevant content]