Cell
Feb 03, 2022 Volume 185 Issue 3 p401-578
https://www.cell.com/cell/current

Previews
Omicron’s message on vaccines: Boosting begets breadth
Duane R. Wesemann
In this issue of Cell, three studies confirm that SARS-CoV-2 Omicron strongly evades a key immune defense—neutralizing antibodies. However, while one- or two-dose vaccine regimens fail to induce anti-Omicron neutralizing antibodies, a homologous third-dose booster rescues neutralization function in a way that highlights the adaptability of immune memory, where recalled immunity extends antibody reach across SARS-CoV-2 variants.