Pre-Print Servers

 

Gates Open Research
https://gatesopenresearch.org/browse/articles
[Accessed 12 Feb 2022]

Research Article metrics AWAITING PEER REVIEW
Modeling anticipated changes in numbers of SARS-CoV-2 infections within communities due to immunization campaigns [version 1; peer review: awaiting peer review]
Kurt Frey, Brittany Hagedorn, Kevin A. McCarthy, Raymond Hutubessy, Susan Annemarie Wang
Peer Reviewers Invited
Funder
Global Good Fund
PUBLISHED 09 Feb 2022

 

medRxiv
https://www.medrxiv.org/content/about-medrxiv
medRxiv is a free online archive and distribution server for complete but unpublished manuscripts (preprints) in the medical, clinical, and related health sciences. Preprints are preliminary reports of work that have not been certified by peer review. They should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information. medRxiv is for the distribution of preprints – complete but unpublished manuscripts – that describe human health research conducted, analyzed, and interpreted according to scientific principles…

Impact of COVID-19 pandemic and anti-pandemic measures on tuberculosis, viral hepatitis, HIV/AIDS and malaria – a systematic review
Barbora Kessel, Torben Heinsohn, Jördis J Ott, Jutta Wolff, Max J Hassenstein, Berit Lange
medRxiv 2022.02.10.22270782; doi: https://doi.org/10.1101/2022.02.10.22270782

Fundamental limits on inferring epidemic resurgence in real time using effective reproduction numbers
Kris V Parag, Christl A. Donnelly
medRxiv 2021.09.08.21263270; doi: https://doi.org/10.1101/2021.09.08.21263270

SARS-CoV-2 neutralization after mRNA vaccination and variant breakthrough infection
Christian Gaebler, Justin DaSilva, Eva Bednarski, Frauke Muecksch, Fabian Schmidt, Yiska Weisblum, Katrina Millard, Martina Turroja, Alice Cho, Zijun Wang, Marina Caskey, Michel C. Nussenzweig, Paul Bieniasz, Theodora Hatziioannou
medRxiv 2022.02.09.22270692; doi: https://doi.org/10.1101/2022.02.09.22270692

Long term antibody response to SARS-CoV-2 in children
Gabor A. Dunay, Madalena Barroso, Mathias Woidy, Marta K. Danecka, Geraldine Engels, Katharina Hermann, Friederike S. Neumann, Kevin Paul, Jan Beime, Gabriele Escherich, Kristin Fehse, Lev Grinstein, Franziska Haniel, Luka J. Haupt, Laura Hecher, Torben Kehl, Christoph Kemen, Markus J. Kemper, Robin Kobbe, Aloisa Kohl, Thomas Klokow, Dominik Noerz, Jakob Olfe, Friderike Schlenker, Jessica Schmiesing, Johanna Schrum, Freya Sibbertsen, Philippe Stock, Stephan Tiede, Eik Vettorazzi, Dimitra E. Zazara, Antonia Zapf, Marc Luetgehetmann, Jun Oh, Thomas S. Mir, Ania C. Muntau, C19.CHILD Study Group, Soeren W. Gersting
medRxiv 2022.02.11.22270611; doi: https://doi.org/10.1101/2022.02.11.22270611

COVID-19 vaccine hesitancy in diverse groups in the UK – is the driver economic or cultural in student populations?
Francis Drobniewski, Dian Kusuma, Agnieszka Broda, Enrique Castro-Sanchez, Raheelah Ahmad
medRxiv 2021.12.14.21267773; doi: https://doi.org/10.1101/2021.12.14.21267773

Ethnic disparities in immunisation: analyses of zero-dose prevalence in 64 low- and middle-income countries
Bianca Oliveira Cata-Preta, Thiago Melo Santos, Andrea Wendt, Daniel R Hogan, Tewodaj Mengistu, Aluisio Jardim Dornellas Barros, Cesar Gomes Victora
medRxiv 2022.02.09.22270671; doi: https://doi.org/10.1101/2022.02.09.22270671
Abstract
Background The Sustainable Development Goals (SDGs) recommend stratification of health indicators by ethnic group, yet there are few studies that have assessed if there are ethnic disparities in childhood immunisation in low and middle income countries (LMICs).
Methods We identified 64 LMICs with standardized national surveys carried out since 2010, which provided information on ethnicity or a proxy variable and on vaccine coverage; 339 ethnic groups across the 64 countries were identified after excluding those with fewer than 50 children in the sample and countries with a single ethnic group. Lack of vaccination with diphtheria-pertussis-tetanus (DPT) vaccine, a proxy for no access to routine vaccination or zero-dose status, was the outcome of interest. Differences among ethnic groups were assessed using a chi-squared test for heterogeneity. Additional analyses controlled for household wealth, maternal education and urban-rural residence.
Findings The median gap between the highest and lowest zero-dose prevalence ethnic groups in all countries was equal to 10 percentage points (interquartile range 4-22; range 1 to 84) and the median ratio was 3.3 (interquartile range 1.8-6.7; range 1.1-30.4). In 35 of the 64 countries, there was significant heterogeneity in zero-dose prevalence among the ethnic groups. In most countries, adjustment for wealth, education and residence made little difference to the ethnic gaps, but in four countries (Angola, Benin, Nigeria, and Philippines) the high-low ethnic gap decreased by over 15 pp after adjustment. Children belonging to a majority group had 29% lower prevalence of zero-dose compared to the rest of the sample.
Interpretation Statistically significant ethnic disparities in child immunisation were present in over half of the countries studied. Such inequalities have been seldom described in the published literature. Regular analyses of ethnic disparities are essential for monitoring trends, targeting resources and assessing the impact of health interventions to ensure zero-dose children are not left behind in the Sustainable Development Goals era.

How many relevant SARS-CoV-2 variants might we expect in the future?
Roberto Littera, Maurizio Melis
medRxiv 2021.11.17.21266463; doi: https://doi.org/10.1101/2021.11.17.21266463

Safety and Efficacy of Preventative COVID Vaccines: The StopCoV Study
Sharon Walmsley, Leah Szadkowski, Bradly Wouters, Rosemarie Clarke, Karen Colwill, Paula Rochon, Michael Brudno, Rizani Ravindran, Janet Raboud, Allison McGeer, Amit Oza, Christopher Graham, Amanda Silva, Dorin Manase, Laura Parente, Jacqueline Simpson, Roaya Monica Dayam, Adrian Pasculescu, Anne-Claude Gingras
medRxiv 2022.02.09.22270734; doi: https://doi.org/10.1101/2022.02.09.22270734

Model-based estimates of deaths averted and cost per life saved by scaling-up mRNA COVID-19 vaccination in low and lower-middle income countries in the COVID-19 Omicron variant era
Alexandra Savinkina, Alyssa Bilinski, Meagan C. Fitzpatrick, A. David Paltiel, Zain Rizvi, Joshua A. Salomon, Tommy Thornhill, Gregg Gonsalves
medRxiv 2022.02.08.22270465; doi: https://doi.org/10.1101/2022.02.08.22270465
[See Featured Journal Articles above for detail]

A recombinant BCG-based vaccine against the human respiratory syncytial virus induces a balanced cellular immune response against viral and mycobacterial antigens
Gaspar A. Pacheco, Nicolás M. S. Gálvez, Catalina A. Andrade, Yaneisi Vázquez, Linmar Rodríguez-Guilarte, Pablo A. González, Susan M. Bueno, Alexis M. Kalergis
medRxiv 2022.02.07.22270648; doi: https://doi.org/10.1101/2022.02.07.22270648

Clinical and Economic Impact of COVID-19 on Plantation Workers: Preliminary Results from the Guatemala Agricultural Workers and Respiratory Illness Impact (AGRI) Study
Daniel Olson, Diva M. Calvimontes, Molly M. Lamb, Gerber Guzman, Edgar Barrios, Andrea Chacon, Neudy Rojop, Kareen Arias, Melissa Gomez, Guillermo Antonio Bolanos, Jose Monzon, Anna N. Chard, Chelsea Iwamoto, Lindsey M. Duca, Nga Vuong, Melissa Fineman, Kelsey Lesteberg, David Beckham, Mario L. Santiago, Kendra Quicke, Gregory Ebel, Emily Zielinski Gutierrez, Eduardo Azziz-Baumgartner, Frederick G. Hayden, Hani Mansour, Kathryn Edwards, Lee S. Newman, Edwin J. Asturias
medRxiv 2022.02.07.22270274; doi: https://doi.org/10.1101/2022.02.07.22270274

A “step too far” or “perfect sense”? A qualitative study of British adults’ views on mandating COVID-19 vaccination and vaccine passports
Martine Stead, Allison Ford, Douglas Eadie, Hannah Biggs, Claire Elliott, Michael Ussher, Helen Bedford, Kathryn Angus, Kate Hunt, Anne Marie MacKintosh, Curtis Jessop, Andy MacGregor
medRxiv 2022.02.07.22270458; doi: https://doi.org/10.1101/2022.02.07.22270458

Time to reinfection and vaccine breakthrough SARS-CoV-2 infections: a retrospective cohort study
Sevda Molani, Andrew M. Baumgartner, Yeon Mi Hwang, Venkata R. Duvvuri, Jason D. Goldman, Jennifer J. Hadlock
medRxiv 2022.02.07.22270613; doi: https://doi.org/10.1101/2022.02.07.22270613

Effectiveness of Covid-19 Vaccines against the SARS-COV-2-Delta (B.1.617.2) in China-A Real World Study
Xinge Ma, Jianfeng Han, Hongxia Li, Chang Liu
medRxiv 2022.02.07.22270490; doi: https://doi.org/10.1101/2022.02.07.22270490

Wellcome Open Research [to 12 Feb 2022]
https://wellcomeopenresearch.org/browse/articles
[Accessed 12 Feb 2022]

Wellcome Open Research provides all Wellcome researchers with a place to rapidly publish any results they think are worth sharing. All articles benefit from rapid publication, transparent peer review and editorial guidance on making all source data openly available.

Research Article metrics AWAITING PEER REVIEW
Impact of the COVID-19 pandemic on routine surveillance for adults with chronic hepatitis B virus (HBV) infection in the UK [version 1; peer review: awaiting peer review]
Cori Campbell, Tingyan Wang, David A. Smith, Oliver Freeman, Theresa Noble, Kinga A Várnai, Steve Harris, Hizni Salih, Gail Roadknight, Stephanie Little, Ben Glampson, Luca Mercuri, Dimitri Papadimitriou, Christopher R Jones, Vince Taylor, Afzal Chaudhry, Hang Phan, Florina Borca, Josune Olza, Frazer Warricker, Luis Romão, David Ramlakhan, Louise English, Paul Klenerman, Monique I. Andersson, Jane Collier, Eleni Nastouli, Salim I. Khakoo, William Gelson, Graham S. Cooke, Kerrie Woods, Jim Davies, Eleanor Barnes, Philippa C. Matthews
Peer Reviewers Invited
Funders
Wellcome Trust
GlaxoSmithKline
NIHR Oxford Biomedical Research Centre
PUBLISHED 11 Feb 2022

Research Article metrics AWAITING PEER REVIEW
Public attitudes to a human challenge study with SARS-CoV-2: a mixed-methods study [version 1; peer review: awaiting peer review]
Caroline Barker, Katharine Collet, Diane Gbesemete, Maria Piggin, Daniella Watson, Philippa Pristerà, Wendy Lawerence, Emma Smith, Michael Bahrami-Hessari, Halle Johnson, Katherine Baker, Ambar Qavi, Carmel McGrath, Christopher Chiu, Robert C. Read, Helen Ward
Peer Reviewers Invited
Funders
Wellcome
GCRF Networks in Vaccines Research and Development
National Institute of Health Research
PUBLISHED 10 Feb 2022

Open Letter metrics
Revised
Towards a feminist philosophy of engagements in health-related research [version 2; peer review: 2 approved]
Sonja Erikainen, Ellen Stewart, Angela Marques Filipe, Sarah Chan, Sarah Cunningham-Burley, Sophie Ilson, Gabrielle King, Carol Porteous, Stephanie Sinclair, Jamie Webb
Peer Reviewers Mary Madden; Kieran C. O’Doherty
Funder
Wellcome Trust
LATEST VERSION PUBLISHED 10 Feb 2022

Open Letter metrics AWAITING PEER REVIEW
A network of empirical ethics teams embedded in research programmes across multiple sites: opportunities and challenges in contributing to COVID-19 research and responses [version 1; peer review: awaiting peer review]
Nothando Ngwenya, Jennifer Ilo Van Nuil, Deborah Nyirenda, Mary Chambers, Phaik Yeong Cheah, Janet Seeley, Primus Chi, Lindiwe Mafuleka, Busisiwe Nkosi, Dorcas Kamuya, Alun Davies, Mira Leonie Schneiders, Noni Mumba, Siphephelo Dlamini, Nicola Desmond, Vicki Marsh, Dinnah Rippon, Michael Parker, Sassy Molyneux
Peer Reviewers Invited
Funder
Wellcome Trust
PUBLISHED 10 Feb 2022
Abstract
Covid-19 continues to teach the global community important lessons about preparedness for research and effective action to respond to emerging health threats.  We share the COVID-19 experiences of a pre-existing cross-site ethics network-the Global Health Bioethics Network-which brings together researchers and practitioners from Africa, Europe, and South east Asia. We describe the network and its members and activities, and the work-related opportunities and challenges we faced over a one-year period during the pandemic. We highlight the value of having strong and long-term empirical ethics networks embedded across diverse research institutions to be able to: 1) identify and share relevant ethics challenges and research questions and ways of ’doing research’; 2) work with key stakeholders to identify appropriate ways to contribute to the emerging health issue response – e.g. through ethics oversight, community engagement, and advisory roles at different levels; and 3) learn from each other and from diverse contexts to advocate for positive change at multiple levels. It is our view that being both embedded and long term offers particular opportunities in terms of deep institutional and contextual knowledge and relationships with and access to a wide range of stakeholders in place. Being networked offers opportunities to draw upon a wide range of expertise and perspectives operating at multiple levels, and to bring together internal and external perspectives (i.e. different positionalities). Long term funding means that the people and resources are in place and ready to respond in a timely way. However, many tensions and challenges remain, including difficulties in negotiating power and politics regarding roles that researchers and research institutions play in an emergency, and the position of empirical ethics activities in programmes of research more specifically. We discuss some of these tensions and challenges, and consider the implications for our own and similar networks in future.