Our World in Data Coronavirus (COVID-19) Vaccinations[Accessed 16 Apr 2022] 65% of the world population has received at least one dose of a COVID-19 vaccine. 11.45 billion doses have been administered globally, and 11.79 million are now administered each day. Only 15.2% of people in low-income countries have received at least one dose.
FDA Takes Important Steps to Increase Racial and Ethnic Diversity in Clinical Trials Agency’s Focus on Inclusion in Trials for All Medical Products Aligns with Biden Administration’s Cancer Moonshot Goal of Addressing Inequities and Beyond
April 13, 2022
Today, the U.S. Food and Drug Administration issued a new draft guidance to industry for developing plans to enroll more participants from underrepresented racial and ethnic populations in the U.S. into clinical trials – expanding on the agency’s previous guidances for industry to improve clinical trial diversity.
“The U.S. population has become increasingly diverse, and ensuring meaningful representation of racial and ethnic minorities in clinical trials for regulated medical products is fundamental to public health,” said FDA Commissioner Robert M. Califf, M.D. “Going forward, achieving greater diversity will be a key focus throughout the FDA to facilitate the development of better treatments and better ways to fight diseases that often disproportionately impact diverse communities. This guidance also further demonstrates how we support the Administration’s Cancer Moonshot goal of addressing inequities in cancer care, helping to ensure that every community in America has access to cutting-edge cancer diagnostics, therapeutics and clinical trials.”
Despite having a disproportionate burden for certain diseases, racial and ethnic minorities are frequently underrepresented in biomedical research. Clinical trials provide a crucial base of evidence for evaluating whether a medical product is safe and effective; therefore, enrollment in clinical trials should reflect the diversity of the population that is ultimately going to use the treatment. It is known that biological differences exist in how people respond to certain therapies. For example, variations in genetic coding can make a treatment more or less toxic for one racial or ethnic group than another. These variations can also make drugs like antidepressants and blood-pressure medications less effective for certain groups.
White House [U.S.] [to 16 Apr 2022] Briefing Room– Selected Major COVID Announcements Press Statement – COVID Context No new digest content identified.
USAID Announces $18 Million Contribution to Education Cannot Wait
April 13, 2022
Press Release
The U.S. Agency for International Development (USAID) will contribute an additional $18 million to Education Cannot Wait (ECW), the major global fund for education in emergencies. USAID announced the additional funding during ECW’s scoping visit to Moldova to support the response to the crisis in Ukraine.
USAID and LIXIL Announce $10 Million to Confront the Global Sanitation Crisis
April 12, 2022
Today, the U.S. Agency for International Development and LIXIL, a global housing and sanitation products multinational company, launched the Partnership for Better Living to expand access to affordable sanitation and hygiene solutions for the underserved in up to 11 countries across sub-Saharan Africa and Asia by 2026.
Government of India – Press Information Bureau Latest Press Releases COVID – 19 Vaccination Update – Day 456 :: India’s cumulative vaccination coverage crosses 186.49 Crore :: More than 11 lakh Vaccine doses administered today till 7 pm :: More than 2.42 Crore Vaccine Doses administered to 12-14 age group so far Posted On: 16 APR 2022 8:05PM by PIB Delhi
[We did not identify official announcements about Shanghai confirming the reports below; See China CDC below for additional announcements]
China tightens controls as Shanghai reports record Covid cases Japan urges local government to address business concerns as ongoing restrictions hit commerce
Reuters in Shanghai
Sat 16 Apr 2022 10.42 EDT
Shanghai reported a record number of symptomatic Covid-19 cases on Saturday and other areas across China tightened controls as the country kept up its “dynamic clearance” approach that aims to stamp out the highly transmissible Omicron variant.
The Zhengzhou airport economic zone, a central Chinese manufacturing area that includes Apple supplier Foxconn, announced a 14-day lockdown on Friday “to be adjusted according to the epidemic situation”…
…Shanghai itself, which is at the centre of China’s recent Covid surge starting in early March, reported a record 3,590 symptomatic cases for 15 April, as well as 19,923 asymptomatic cases. The asymptomatic case number was up slightly from 19,872 cases a day earlier.
The city’s case tally makes up the vast majority of cases nationwide even as most of its 25 million residents remain under lockdown…
At the Zhengzhou economic zone, only personnel with valid passes, health codes and proof of negative Covid tests would be able to leave during the two-week period, although “special vehicles” would be able to travel normally for work reasons, local authorities said in a post on an official WeChat instant messaging account.
Overall, China reported 24,791 new coronavirus cases on 15 April, of which 3,896 were symptomatic and 20,895 were asymptomatic, the National Health Commission said on Saturday.
UN OCHA – Current Emergencies Current Corporate Emergencies Afghanistan No new updates identified.
Northern Ethiopia Ethiopia – Northern Ethiopia Humanitarian Update Situation Report, 14 Apr 2022 HIGHLIGHTS
Humanitarian partners have not been able to move any additional aid supplies into Tigray by road since the convoy entered on 1 and 2 April.
About 36 metric tons of HIV medical supplies were airlifted to Mekelle, the first time since July 2021. It will be enough to provide treatment for 46,000 patients for six months.
Authorities in Amhara relocated more than 20,000 people out of the planned 70,000 people in North Wello and Wag Hamra zones to new designated sites since mid-March.
WFP assisted over 35,000 people with food in Gulina, Barahle and Dalole woredas in Afar during the reporting period, reaching over 235,000 people since last week of February.
More than 11,000 children under five and pregnant and lactating women received supplementary nutrients in Wag Harma and North Wello zones in Amhara between 1 and 10 April.
WHO & Regional Offices [to 16 Apr 2022] https://www.who.int/news News [Selected] 14 April 2022 Departmental news The Global Diabetes Compact: a promising first year
14 April 2022 Departmental news World Chagas Disease Day: finding and reporting every case
13 April 2022 Statement Statement on the eleventh meeting of the International Health Regulations (2005) Emergency Committee regarding the coronavirus disease (COVID-19) pandemic [See Milestones above for detail]
13 April 2022 Departmental news Ukraine next country to receive technology from the WHO mRNA technology transfer hub
12 April 2022 Departmental news Meeting of WHO Director-General’s Expert Group on Cervical Cancer Elimination, 19 April 2022
11 April 2022 Departmental news SAGE April 2022 meeting highlights [See Milestones above for detail]
11 April 2022 News release One-dose Human Papillomavirus (HPV) vaccine offers solid protection against cervical cancer [See Milestones above for detail]
14 April 2022 Speech WHO Director-General’s opening remarks at the Briefing to the African Union Ambassadors in Geneva on Strengthening Local Manufacturing Capacity – 14 April 2022
13 April 2022 Speech WHO Director-General’s opening remarks at the WHO press conference – 13 April 2022
12 April 2022 Speech WHO Director-General’s opening remarks at the International Strategic Dialogue on Noncommunicable Diseases and the Sustainable Development Goals – 12 April 2022
12 April 2022 Speech WHO Director-General’s opening remarks at the Global Launch of the WHO QualityRights e-training to advance mental health, eliminate stigma and promote community inclusion – 12 April 2022
12 April 2022 Speech WHO Director-General’s opening remarks at the Public Hearing regarding a new international instrument on pandemic preparedness and response – 12 April 2022
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WHO Regional Offices Selected Press Releases, Announcements WHO African Region
:: Africa witnesses longest-running decline in COVID-19 cases 14 April 2022
Brazzaville – Africa is experiencing its longest-running decline in COVID-19 infections since the onset of the pandemic. Recorded weekly cases have fallen for the past 16 weeks, while deaths have dropped for the last eight.
Infections—largely due to the Omicron-driven fourth pandemic wave—have tanked from a peak of over 308 000 cases weekly at the start of the year to less than 20 000 in the week ending on 10 April 2022. Over the past week, around 18 000 cases and 239 deaths were recorded, a decline of 29% and 37% respectively compared with the week before. This low level of infection has not been seen since April 2020 in the early stages of the pandemic in Africa…
:: Botswana, South Africa deepen probe into new Omicron sub-variants 12 April 2022
Brazzaville – Researchers in Botswana and South Africa have detected new sub-lineages of the Omicron variant of the SARS-CoV-2 and are carrying out further investigations to fully understand crucial traits such as infectivity and virulence.
The identified sub-lineages variant are BA.4 and BA.5. World Health Organization (WHO) experts are working with scientists and researchers in the two countries to deepen analysis of the sub-lineages which have so far been identified in four people in Botswana and 23 in South Africa. Outside Africa, the BA.4 and the BA.5 have been confirmed in Belgium, Denmark, Germany and the United Kingdom…
:: Deaths from noncommunicable diseases on the rise in Africa 11 April 2022
Accra/Brazzaville – Noncommunicable diseases such as cancer, cardiovascular diseases and diabetes are increasingly becoming the main cause of mortality in sub-Saharan Africa, where the diseases were responsible for 37% of deaths in 2019, rising from 24% in 2000 largely due to weaknesses in the implementation of critical control measures including prevention, diagnosis and care. This comes on the eve of a high-level heads of state and health leaders meeting in Ghana to find ways of accelerating progress against noncommunicable diseases…
WHO Region of the Americas PAHO
:: 13 Apr 2022 Less than 10% of those infected with Chagas disease receive timely diagnosis and treatment
PAHO calls for detection of all cases and equitable access to care for this disease, which causes about 30,000 new infections each year. Washington, DC, April 13, 2022 (PAHO)- Due to its silent nature, less than 10% of those infected with Chagas disease each year receive timely diagnosis and, therefore, effective treatment in Mexico, Central…
:: 11 Apr 2022 One-dose Human Papillomavirus (HPV) vaccine offers solid protection against cervical cancer
Geneva, 11 April 2022 (WHO)- The 4-7 April convening of the WHO Strategic Advisory Group of Experts on Immunization (SAGE) evaluated the evidence that has been emerging over past years that single-dose schedules provide comparable efficacy to the two or three-dose regimens. SAGE’s review concluded that a single-dose Human Papillomavirus (HPV)…
New WHO Publications https://www.who.int/publications/i Selected Titles
14 April 2022 Environmental surveillance for SARS-COV-2 to complement public health surveillance – Interim Guidance Overview
Routine diagnostic surveillance for COVID-19 has been augmented with environmental surveillance (ES) in wastewater in many locations. ES provides additional evidence on virus in circulation at population level including presence or absence, early warning of increasing or decreasing trends, and information on variants of concern or interest.
This guidance provides advice on:
What situations ES has been shown to add value to public health decision making
What is needed to plan and coordinate an effective ES programme
How to carry out data collection, analysis, interpretation and communication of results.
This guidance is targeted at public health officials who want to understand and integrate complementary ES into COVID-19 control strategies.
ACIP Meetings
Next ACIP Meeting April 20, 2022 11:00am – 4:00pm ET.
This meeting is virtual. No registration is required to watch the webcasts. Webcast Link No Agenda posted at inquiry
Careful readers will note that the number and range of organizations now monitored in our Announcements section below has grown as the impacts of the pandemic have spread across global economies, supply chains and programmatic activity of multilateral agencies and INGOs.
The Bill & Melinda Gates Medical Research Institute is a non-profit biotech organization. Our mission is to develop products to fight malaria, tuberculosis, and diarrheal diseases—three major causes of mortality, poverty, and inequality in developing countries. The world has unprecedented scientific tools at its disposal; now is the time to use them to save the lives of the world’s poorest people
The European & Developing Countries Clinical Trials Partnership (EDCTP) aims to accelerate the development of new or improved drugs, vaccines, microbicides and diagnostics against HIV/AIDS, tuberculosis and malaria as well as other poverty-related and neglected infectious diseases in sub-Saharan Africa, with a focus on phase II and III clinical trials
Statement by the International Committee of the Red Cross (ICRC) at the United Nations Security Council, New York 11 April 2022. Delivered by Dr. Esperanza Martinez, Senior Advisor to the Office of the Director-General.
12-04-2022 | Statement
[See COVID above for detail]
International Coalition of Medicines Regulatory Authorities [ICMRA]
ISC is a non-governmental organization with a unique global membership that brings together 40 international scientific Unions and Associations and over 140 national and regional scientific organizations including Academies and Research Councils.
During World Immunization Week 2022 the International Vaccine Access Center, along with global immunization and indigenous health partners, will host a three webinars. Registration is free, and we encourage all to sign up and save these dates on their calendars. Enabling Equitable Access to COVID-19 Vaccines for Indigenous Populations When: April 26, 2022 from 6:00 […]
Foreign aid from official donors rose to an all-time high of USD 179 billion in 2021, up 4.4% in real terms from 2020 as developed countries stepped up their help for developing countries grappling with the COVID-19 crisis, according to preliminary data collected by the OECD.
… Unitaid’s efforts, underway in Brazil, Bolivia, Colombia and Paraguay, seek to demonstrate new approaches to testing, treatment and care for Chagas disease that will generate valuable evidence to facilitate the adoption of feasible and cost-effective health strategies for combatting Chagas disease across the region and globally…
BRUSSELS, April 14, 2022 – Green fiscal reforms can help protect vulnerable households and support pandemic recovery efforts in European countries on the road to climate neutrality by 2050, says a new…
Proposed actions to help vulnerable countries include providing emergency food supplies and deploying financial support to households and countries; facilitating unhindered trade; investing in sustainable…
Proposed actions to help vulnerable countries include providing emergency food supplies and deploying financial support to households and countries; facilitating unhindered trade; investing in sustainable…
The heads of the World Bank, the International Monetary Fund (IMF), the United Nations World Food Program (WFP) and the WTO issued a joint statement on 13 April urging coordinated action to help vulnerable countries address growing threats to food security. The proposed actions include providing emergency food supplies and deploying financial support to households and countries, facilitating unhindered trade, and investing in sustainable food production and nutrition security.
The World Health Organization (WHO), the World Intellectual Property Organization (WIPO) and the WTO launched on 11 April 2022 their new Trilateral COVID-19 Technical Assistance Platform. This new tool aims to help members and WTO accession candidates address their capacity building needs to respond to the COVID-19 pandemic.
[See COVID above for detail]
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ARM [Alliance for Regenerative Medicine] [to 16 Apr 2022]
The biopharmaceutical industry is committed to working with stakeholders to improve pandemic preparedness for the future and to ensure equitable access to medical countermeasures.
Any system should be built on what worked well during the COVID-19 pandemic with robust IP frameworks enabling collaborations, as well as immediate sharing of pathogens.
As the INB enters deeper discussions on a new instrument we believe these should be informed by a few core principles:
International Generic and Biosimilar Medicines Association [IGBA]
Journal Watch Vaccines and Global Health: The Week in Review continues its weekly scanning of key peer-reviewed journals to identify and cite articles, commentary and editorials, books reviews and other content supporting our focu-s on vaccine ethics and policy. Journal Watch is not intended to be exhaustive, but indicative of themes and issues the Center is actively tracking. We selectively provide full text of some editorial and comment articles that are specifically relevant to our work. Successful access to some of the links provided may require subscription or other access arrangement unique to the publisher.
If you would like to suggest other journal titles to include in this service, please contact David Curry at: david.r.curry@centerforvaccineethicsandpolicy.org
Health Equity in US Latinx Communities
Latinx communities in the US include over 60 million people with a plurality of political beliefs, cultural practices, and wealth. This diversity is also expressed in population health data: some health indicators suggest advantages of Latinx community membership while other data demonstrate inequitable disease burden and maldistribution of environmental and occupational risk. Legacies of colonial conquest of the Americas persist in discrimination and marginalization today and are embodied by members of our Latinx communities.
(Accessed 16 Apr 2022) Studying SARS-CoV-2 vaccine hesitancy among health professionals in Tunisia People’s lives were seriously affected by the emergence and the spread of the COVID-19 disease. Several vaccines were developed in record time to overcome this pandemic. However, putting an end to this public …
Authors: Nawel Zammit, Amani El Gueder, Aïcha Brahem, Imen Ayouni, Rim Ghammam, Sihem Ben Fredj, Chaima Sridi, Asma Chouchene, Houda Kalboussi, Olfa El Maalel, Souhaeil Chatti, Jihene Maatoug, Hassen Ghannem and Néjib Mrizak
Citation: BMC Health Services Research 2022 22:489
Content type: Research Published on: 12 April 2022
Children with SARS-CoV-2 infection during the novel coronaviral disease (COVID-19) outbreak in Iran: an alarming concern for severity and mortality of the disease The rapid worldwide spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections led to public health crises globally and the number of pediatric patients with Coronavirus Disease 2019 (CO…
Authors: Setareh Mamishi, Babak Pourakbari, Mehrzad Mehdizadeh, Amene Navaeian, Hamid Eshaghi, Bahareh Yaghmaei, Reihaneh Hosseinpour Sadeghi, Shiva Poormohammadi, Yasmine Mahmoudieh and Shima Mahmoudi
Citation: BMC Infectious Diseases 2022 22:382
Content type: Research article Published on: 15 April 2022
Determinants of measles vaccination dropout among 12 − 23 months aged children in pastoralist community of Afar, Ethiopia Measles is a viral disease and a leading vaccine-preventable childhood killer. More than 95% of measles deaths occur in countries with low incomes and weak health infrastructures. In response to this, Ethiopia…
Authors: Chekole Hailu, Girmatsion Fisseha and Aregawi Gebreyesus
Citation: BMC Infectious Diseases 2022 22:376
Content type: Research article Published on: 14 April 2022
Barriers to and strategies to address COVID-19 testing hesitancy: a rapid scoping review Testing is a foundational component of any COVID-19 management strategy; however, emerging evidence suggests that barriers and hesitancy to COVID-19 testing may affect uptake or participation and often these a…
Authors: Mark Embrett, S. Meaghan Sim, Hilary A. T. Caldwell, Leah Boulos, Ziwa Yu, Gina Agarwal, Rhiannon Cooper, Allyson J. Gallant AJ, Iwona A. Bielska, Jawad Chishtie, Kathryn Stone, Janet Curran and Andrea Tricco
Citation: BMC Public Health 2022 22:750
Content type: Research Published on: 14 April 2022
Considering social inequalities in health in large-scale testing for COVID-19 in Montréal: a qualitative case study Evidence continues to demonstrate that certain marginalised populations are disproportionately affected by COVID-19. While many studies document the impacts of COVID-19 on social inequalities in health, none h…
Authors: Marie-Catherine Gagnon-Dufresne, Lara Gautier, Camille Beaujoin, Ashley Savard Lamothe, Rachel Mikanagu, Patrick Cloos, Valéry Ridde and Kate Zinszer
Citation: BMC Public Health 2022 22:749
Content type: Research Published on: 14 April 2022
Prioritizing COVID-19 vaccination efforts and dose allocation within Madagascar While mass COVID-19 vaccination programs are underway in high-income countries, limited availability of doses has resulted in few vaccines administered in low and middle income countries (LMICs). The COVID-19 …
Authors: Fidisoa Rasambainarivo, Tanjona Ramiadantsoa, Antso Raherinandrasana, Santatra Randrianarisoa, Benjamin L. Rice, Michelle V. Evans, Benjamin Roche, Fidiniaina Mamy Randriatsarafara, Amy Wesolowski and Jessica C. Metcalf
Citation: BMC Public Health 2022 22:724
Content type: Research Published on: 12 April 2022
A network of change: united action on research integrity
Authors: Thomas Rhys Evans, Madeleine Pownall, Elizabeth Collins, Emma L. Henderson, Jade S. Pickering, Aoife O’Mahony, Mirela Zaneva, Matt Jaquiery and Tsvetomira Dumbalska
Citation: BMC Research Notes 2022 15:141
Content type: Commentary Published on: 14 April 2022 Abstract
The last decade has seen renewed concern within the scientific community over the reproducibility and transparency of research findings. This paper outlines some of the various responsibilities of stakeholders in addressing the systemic issues that contribute to this concern. In particular, this paper asserts that a united, joined-up approach is needed, in which all stakeholders, including researchers, universities, funders, publishers, and governments, work together to set standards of research integrity and engender scientific progress and innovation. Using two developments as examples: the adoption of Registered Reports as a discrete initiative, and the use of open data as an ongoing norm change, we discuss the importance of collaboration across stakeholders.
Conversations Learning lessons from lipids to make COVID-19 vaccines
A game-changing intervention in the COVID-19 pandemic has been the rapid implementation of highly effective vaccines against SARS-CoV-2. The 2022 Canada Gairdner International Award recognizes Pieter Cullis, Katalin Karikó, and Drew Weissman “for their pioneering work developing nucleoside-modified mRNA and lipid nanoparticle (LNP) drug delivery: the foundational technologies for the highly effective COVID-19 mRNA vaccines.” Cell editor Cheri Sirois caught up with Pieter to discuss how a long interest in basic and applied questions in lipid biology led to this fortuitous collaboration. Excerpts of the conversation are presented below.
Voices The voices of Ukrainian and Russian scientists
Rostyslav Stoika, Nikita Gudimchuk, Halyna R. Shcherbata, Andrey Zaraisky, Oleksandr Shcheglovitov,
Yevgenia Kozorovitskiy, Viktor Korolchuk
The brutal attack on Ukraine by the Russian Federation has shocked the world. While the world works to end the violence and help refugees, as a scientific journal, our thoughts are also with those in the scientific community who are directly or indirectly impacted by the war. We have been inspired by and applaud the labs around the world that have opened their doors to displaced scientists and remain committed to supporting scientists, whoever and wherever they are. Because science requires collaboration and trust, we urge the scientific community to continue efforts like this and to remain united, especially in times as difficult as these. In this Voices piece, we feature short comments from scientists from Ukraine and scientists from Russia. This small sampling is far from exhaustive, but our sincere thanks go to those scientists who were willing to share their thoughts on this volatile and emotionally charged situation; the views expressed are those of the contributors alone. We join the world in hoping for a swift resolution to the conflict, for the good of humanity.
Therapeutic Innovations in Neuroscience
The theme of this issue of Clinical Pharmacology & Therapeutics (CPT) encompasses neuroscience in the broad sense to include neurology and psychiatry, nonclinical and clinical aspects, novel clinical trial methodologies, and modeling and simulation approaches applicable to central nervous system (CNS) drug development and therapy. While naturally the last two years have been dominated by coronavirus disease 2019 (COVID-19), it is important not to forget that drug development for other indications has not been stopped, albeit many trials were affected in terms of delays in recruitment and collection of clinical data.
What is the impact of intellectual property rules on access to medicines? A systematic review It is widely accepted that intellectual property legal requirements such as patents and data exclusivity can affect access to medicines, but to date there has not been a comprehensive review of the empirical e…
Authors: Brigitte Tenni, Hazel V. J. Moir, Belinda Townsend, Burcu Kilic, Anne-Maree Farrell, Tessa Keegel and Deborah Gleeson
Citation: Globalization and Health 2022 18:40
Content type: Review Published on: 15 April 2022
Analysis | 06 April 2022 | Open Access A joint NCBI and EMBL-EBI transcript set for clinical genomics and research
Matched Annotation from NCBI and EMBL-EBI (MANE) delivers joint transcript sets from Ensembl/GENCODE and RefSeq for standardizing variant reporting in clinical genomics and research.
Joannella Morales, Shashikant Pujar, Terence D. Murphy
Editorial | 04 April 2022 Licensing for profit and for good
The Broad Institute’s enlightened licensing approach to CRISPR–Cas9 intellectual property stands out in the otherwise regrettable spat for patent rights over the foundational technology.
Article | 11 April 2022 Expanded COVID-19 phenotype definitions reveal distinct patterns of genetic association and protective effects
GWASs based on self-reported phenotypes in 736,723 individuals show distinct associations between risk loci and eight COVID-19 outcomes, suggesting differences in genetic susceptibility to infection upon exposure and severe and symptomatic disease.
Genevieve H. L. Roberts, Raghavendran Partha, Kristin A. Rand
Analysis | 28 March 2022 | Open Access Global landscape of SARS-CoV-2 genomic surveillance and data sharing
Analyses on the global diversity of SARS-CoV-2 genomic surveillance across 118 countries and the extent of public availability of genomic data provide evidence to better inform SARS-CoV-2 surveillance policy.
Zhiyuan Chen, Andrew S. Azman, Hongjie Yu
Biosecurity in an age of open science
James Andrew Smith, Jonas B. Sandbrink
Essay | published 14 Apr 2022 PLOS Biology https://doi.org/10.1371/journal.pbio.3001600 Abstract
The risk of accidental or deliberate misuse of biological research is increasing as biotechnology advances. As open science becomes widespread, we must consider its impact on those risks and develop solutions that ensure security while facilitating scientific progress. Here, we examine the interaction between open science practices and biosecurity and biosafety to identify risks and opportunities for risk mitigation. Increasing the availability of computational tools, datasets, and protocols could increase risks from research with misuse potential. For instance, in the context of viral engineering, open code, data, and materials may increase the risk of release of enhanced pathogens. For this dangerous subset of research, both open science and biosecurity goals may be achieved by using access-controlled repositories or application programming interfaces. While preprints accelerate dissemination of findings, their increased use could challenge strategies for risk mitigation at the publication stage. This highlights the importance of oversight earlier in the research lifecycle. Preregistration of research, a practice promoted by the open science community, provides an opportunity for achieving biosecurity risk assessment at the conception of research. Open science and biosecurity experts have an important role to play in enabling responsible research with maximal societal benefit.