Annals of Internal Medicine
July 2021 Volume 174, Issue 7
http://annals.org/aim/issue

Position Papers
Health Information Privacy, Protection, and Use in the Expanding Digital Health Ecosystem: A Position Paper of the American College of Physicians
FREE
Brooke Rockwern, MPH, Dejaih Johnson, JD, MPA, Lois Snyder Sulmasy, JD,
Pages:994–998
Abstract
Technologic advancements and the evolving digital health landscape have offered innovative solutions to several of our health care system’s issues as well as increased the number of digital interactions and type of personal health information that is generated and collected, both within and outside of traditional health care. This American College of Physicians’ position paper discusses the state of privacy legislation and regulations, highlights existing gaps in health information privacy protections, and outlines policy principles and recommendations for the development of health information privacy and security protections that are comprehensive, transparent, understandable, adaptable, and enforceable. The principles and recommendations aim to improve on the privacy framework in which physicians have practiced for decades and expand similar privacy guardrails to entities not currently governed by privacy laws and regulations. The expanded privacy framework should protect personal health information from unauthorized, discriminatory, deceptive, or harmful uses and align with the principles of medical ethics, respect individual rights, and support the culture of trust necessary to maintain and improve care delivery.

Annals of Internal Medicine
July 2021 Volume 174, Issue 7
http://annals.org/aim/issue

Special Articles
Toward Understanding COVID-19 Recovery: National Institutes of Health Workshop on Postacute COVID-19
FREEAndrea M. Lerner, MD, Daphne A. Robinson, PhD, Linda Yang, PhD, Carolyn F. Williams, PhD, MPH, … et al.
Pages:999–1003

BMC Medical Ethics
http://www.biomedcentral.com/bmcmedethics/content
(Accessed 24 Jul 2021)

Gurus and Griots: Revisiting the research informed consent process in rural African contexts
Researchers conducting community-based participatory action research (CBPAR) in highly collectivistic and socioeconomically disadvantaged community settings in sub-Saharan Africa are confronted with the distinctive challenge of balancing universal ethical standards with local standards, where traditional customs or beliefs may conflict with regulatory requirements and ethical guidelines underlying the informed consent (IC) process. The unique ethnic, socioeconomic, and cultural diversities in these settings have important implications for the IC process, such as individual decisional autonomy, beneficence, confidentiality, and signing the IC document.
Authors: Richard Appiah
Citation: BMC Medical Ethics 2021 22:98
Content type: Debate
Published on: 23 July 2021

BMC Public Health
http://bmcpublichealth.biomedcentral.com/articles
(Accessed 24 Jul 2021)

E-health roadmap for COVID-19 vaccine coverage in Iran
Vaccination is the effective and long-term pharmacological solution to deal with COVID-19. Information technology (IT) and electronic immunization can be effective in accelerating and improving vaccine coverag…
Authors: Elham Maserat, Leila Keikha, Somayeh Davoodi and Zeinab Mohammadzadeh
Citation: BMC Public Health 2021 21:1450
Content type: Research
Published on: 23 July 2021

BMC Public Health
http://bmcpublichealth.biomedcentral.com/articles
(Accessed 24 Jul 2021)

Beliefs and barriers associated with COVID-19 vaccination among the general population in Saudi Arabia
Developing a vaccine against COVID-19 is considered a key strategy to end the pandemic. However, public acceptance is reliant on beliefs and perception toward the vaccine. Therefore, the study aimed to assess …
Authors: Rania M. Magadmi and Fatemah O. Kamel
Citation: BMC Public Health 2021 21:1438
Content type: Research article
Published on: 21 July 2021

Clinical Trials

Volume 18 Issue 4, August 2021

https://journals.sagepub.com/toc/ctja/18/4

 Articles
COVID-19 vaccine trials: The potential for “hybrid” analyses
Thomas R Fleming, Martha Nason, Philip R Krause, Ira M Longini, Ana-Maria Henao-Restrepo
First Published May 27, 2021; pp. 391–397

Clinical Trials

Volume 18 Issue 4, August 2021

https://journals.sagepub.com/toc/ctja/18/4

Recruitment and Retention
Effectiveness of participant recruitment strategies for critical care trials: A systematic review and narrative synthesis
Timia Raven-Gregg, Fiona Wood, Victoria Shepherd
First Published February 2, 2021; pp. 436–448

Developing World Bioethics
Volume 21, Issue 2 June 2021
https://onlinelibrary.wiley.com/toc/14718847/current

Special Issue: Conscientious objection to termination of pregnancy in the global south: legal and ethical challenges
Issue Edited by:  Anita Kleinsmidt

The European Journal of Public Health
SUPPLEMENT – Volume 31, Issue Supplement_1, July 2021
https://academic.oup.com/eurpub/issue/31/Supplement_1

Supplement: E-Mental-Health: Exploring the Evidence Base and Stakeholders’ Perspectives on Internet-Based Interventions for the Prevention of Mental Health Conditions
Mental illness represents an enormous personal, social and societal burden for European citizens1 calling for the need to expand existing models of mental healthcare delivery. In Europe, the Internet is a key source of health information,2 and technology-enhanced (psychological) interventions such as Internet- and mobile-delivered applications (‘eHealth’3 and ‘m-Health’4) have become increasingly popular and studied. There is already strong evidence of the efficacy of online interventions for the prevention and treatment of several psychological disorders5,6 and meta-analyses show effect sizes similar to face-to-face interventions.7

Globalization and Health
http://www.globalizationandhealth.com/
[Accessed 24 Jul 2021]

Conflict and COVID-19 in Yemen: beyond the humanitarian crisis
Yemen has been left in shambles and almost destroyed by its devastating civil war, and is now having to deal with the spread of coronavirus. The Yemeni people have been are left to fend for themselves and face…
Authors: Mohammed Alsabri, Ayman Alhadheri, Luai M. Alsakkaf and Jennifer Cole
Citation: Globalization and Health 2021 17:83
Content type: Commentary
Published on: 22 July 2021

Health Affairs
Vol. 40, No. 7 July 2021
https://www.healthaffairs.org/toc/hlthaff/current

July 2021 | Borders, Immigrants & Health
About one in seven residents of the US is an immigrant, and about fifteen million people live within 100 kilometers of the US-Mexico border. Disparities in health status exist between people born in the US and those who have immigrated. Immigration policy has been contentious throughout US history, and current policies in the US and Mexico have significant effects on the health and well-being of tens of millions of people. This thematic issue of Health Affairs focuses on immigrants and borders. The overview article by Arturo Vargas Bustamante and coauthors describes a range of health policy issues raised by the continuously shifting demography of US immigrants.

Health Research Policy and Systems
http://www.health-policy-systems.com/content
[Accessed 24 Jul 2021]

Rethinking approaches of science, technology, and innovation in healthcare during the COVID-19 pandemic: the challenge of translating knowledge infrastructures to public needs
Authors: Renan Gonçalves Leonel da Silva, Roger Chammas and Hillegonda Maria Dutilh Novaes
Content type: Commentary
21 July 2021
Introduction
The coronavirus 2019 (COVID-19) pandemic has changed how we understand and approach problems in science, technology, and innovation (ST&I) in health in contemporary society. The current situation has produced specific demands for health systems, and an inconvenient paradox has become visible: we have never had such a supply of qualified scientific and technological knowledge infrastructures in health and biomedical sciences, but at the same time a viable translation of this knowledge to public health systems has shown itself flawed and inefficient. This paradox raises questions about what has brought us to this inconvenient reality, and the importance of paying greater attention to the mechanisms of governance and implementation of ST&I in public health in a more systemic way.

Humanitarian Exchange Magazine
Number 79, May 2021
https://odihpn.org/magazine/inclusion-of-persons-with-disabilities-in-humanitarian-action-what-now/

Localisation and local humanitarian action
by HPN October 2020
The theme of this edition of Humanitarian Exchange is localisation+ and local humanitarian action. Five years ago this week, donors, United Nations (UN) agencies,  non-governmental organisations (NGOs), the International Committee of the Red Cross (ICRC) and International Federation of Red Cross and Red Crescent Societies (IFRC) committed within the Grand Bargain to increase multi-year investments in the institutional capacities of local and national responders, and to provide at least 25% of humanitarian funding to them as directly as possible. Since then, there is increasing consensus at policy and normative level, underscored by the Covid-19 pandemic, that local leadership should be supported.  Localisation has gone from a fringe conversation among policy-makers and aid agencies in 2016 to a formal priority under the Grand Bargain. Wider global movements on anti-racism and decolonisation have also brought new momentum to critical reflections on where power, knowledge and capacity reside in the humanitarian system. Yet progress has been slow and major gaps remain between the rhetoric around humanitarian partnerships, funding and coordination and practices on the ground.

Infectious Diseases of Poverty
http://www.idpjournal.com/content
[Accessed 24 Jul 2021]

Multi-level determinants of failure to receive timely and complete measles vaccinations in Southwest China: a mixed methods study
Authors: Xian-Yan Tang, Man Cheng, Alan Geater, Qiu-Yun Deng, Ge Zhong, Yue-Dong Lin, Ning Chen, Tao Lan, Long-Yan Jiang, Man-Tong Zhu and Qiao Li
Content type: Research Article
22 July 2021

International Journal of Infectious Diseases
July 2021 Volume 108 p1-616
https://www.ijidonline.com/current

COVID-19 Collection
An analysis of COVID-19 vaccine sentiments and opinions on Twitter
Samira Yousefinaghani, Rozita Dara, Samira Mubareka, Andrew Papadopoulos, Shayan Sharif
Published online: May 27, 2021
p256-262

JAMA
July 20, 2021, Vol 326, No. 3, Pages 207-286
https://jamanetwork.com/journals/jama/currentissue

Special Communication
Guidelines for Reporting Trial Protocols and Completed Trials Modified Due to the COVID-19 Pandemic and Other Extenuating CircumstancesThe CONSERVE 2021 Statement
Aaron M. Orkin, MD, MSc, MPH; Peter J. Gill, MD, DPhil; Davina Ghersi, MD, PhD; et al.
free access
JAMA. 2021;326(3):257-265. doi:10.1001/jama.2021.9941
This Special Communication describes CONSERVE, a guideline developed to improve the transparency, quality, and completeness of reporting of trials and trial protocols that undergo important modifications in response to extenuating circumstances such as the COVID-19 pandemic.

JAMA
July 20, 2021, Vol 326, No. 3, Pages 207-286
https://jamanetwork.com/journals/jama/currentissue

Viewpoint
Sharing Technology and Vaccine Doses to Address Global Vaccine Inequity and End the COVID-19 Pandemic
Matthew M. Kavanagh, PhD; Lawrence O. Gostin, JD; Madhavi Sunder, JD
free access
JAMA. 2021;326(3):219-220. doi:10.1001/jama.2021.10823
This Viewpoint offers 3 strategies to address inequity in pandemic vaccine response: surge funding, increased funding, and an agreement to share technology and allow countries to waive intellectual property rights in global public health emergencies.

JAMA
July 20, 2021, Vol 326, No. 3, Pages 207-286
https://jamanetwork.com/journals/jama/currentissue

Ethical Considerations of Offering Benefits to COVID-19 Vaccine Recipients
Govind Persad, JD, PhD; Ezekiel J. Emanuel, MD, PhD
free access
JAMA. 2021;326(3):221-222. doi:10.1001/jama.2021.11045
This Viewpoint discusses why offering incentives for COVID-19 vaccination is not only ethical, but an important tool in increasing vaccine uptake, which benefits society as a whole.

JAMA Network
COVID-19 Update July 24, 2021

These articles on COVID-19 were published across the JAMA Network in the last week.

Journal of Health Care for the Poor and Underserved (JHCPU)
Volume 32, Number 2, May 2021 Supplement
https://muse.jhu.edu/issue/44396

Table of Contents
Overview of the Issue
Kevin B. Johnson, Tiffani J. Bright, Cheryl R. Clark
…The importance of techquity—defined as the strategic development and deployment of technology in health care and health to advance health equity—was even more apparent after the events of 2020. COVID-19 upended access to care and illuminated the impact of structural racism as a cause for a widening gap of access during the pandemic. Black Lives Matter became more than a trending hashtag on Twitter, or a movement resulting in peaceful protests and calls for policy reform: it put additional focus on the issue of race as a social and not a biological construct and called into question the rationale for common practices in health care that were triggered by race. A notable example was the emerging realization that kidney function assessment was tied to race and hardwired into many of our electronic health records. The real-world evidence around our lack of techquity was incontrovertible.
This Supplemental Issue of JHCPU provides articles that describe challenges to techquity, frameworks to improve the role of technology in care, and examples of how technology can transform health, public health, and health care…

Journal of Pediatrics
August 2021 Volume 235 p1-306
http://www.jpeds.com/current

Original Articles
Pneumococcal Conjugated Vaccines Decreased Acute Otitis Media Burden: A Population-Based Study in Israel
Tal Marom, Sagi Tshori, Galit Shefer, Jacob Pitaro
Published online: April 21, 2021
p233-238.e3

The Lancet
Jul 17, 2021 Volume 398 Number 10296 p185-276, e7
https://www.thelancet.com/journals/lancet/issue/current

Comment
Five priorities for universal COVID-19 vaccination
Adrien Abecassis
… On May 6, 2021, the Paris Peace Forum (PPF), an international platform dedicated to global governance, convened a high-level meeting, which included government officials and G20 sherpas to heads of states and governments, public health leaders, and members of non-governmental organisations and foundations from 15 countries, to deliberate on how to get closer to universal COVID-19 vaccination in a limited time. The group identified five priorities…

Nature
Volume 595 Issue 7868, 22 July 2021
https://www.nature.com/nature/volumes/595/issues/7868

Article | 27 May 2021
BNT162b2 vaccine induces neutralizing antibodies and poly-specific T cells in humans
In a phase-I/II trial in healthy adults, the BNT162b2 vaccine induces neutralizing antibodies and poly-specific T cells against SARS-CoV-2 epitopes that are conserved in a wide range of currently circulating variants.
Ugur Sahin, Alexander Muik…Özlem Türeci

New England Journal of Medicine
July 22, 2021 Vol. 385 No. 4
http://www.nejm.org/toc/nejm/medical-journal

Original Articles
Prevention and Attenuation of Covid-19 with the BNT162b2 and mRNA-1273 Vaccines M.G. Thompson and Others

PLoS Medicine
http://www.plosmedicine.org/
(Accessed 24 Jul 2021)

Evidence-informed policy for tackling adverse climate change effects on health: Linking regional and global assessments of science to catalyse action
Robin Fears, Khairul Annuar B. Abdullah, Claudia Canales-Holzeis, Deoraj Caussy, Andy Haines, Sherilee L. Harper, Jeremy N. McNeil, Johanna Mogwitz, Volker ter Meulen
Policy Forum | published 20 Jul 2021 PLOS Medicine
https://doi.org/10.1371/journal.pmed.1003719

PLoS Neglected Tropical Diseases
http://www.plosntds.org/

Review
Addressing antimicrobial resistance by improving access and quality of care—A review of the literature from East Africa
Kathrin Loosli, Alicia Davis, Adrian Muwonge, Tiziana Lembo
| published 22 Jul 2021 PLOS Neglected Tropical Diseases
https://doi.org/10.1371/journal.pntd.0009529

PLoS One
http://www.plosone.org/
[Accessed 24 Jul 2021]

Ethical review of COVID-19 research in the Netherlands; a mixed-method evaluation among medical research ethics committees and investigators
R. IJkema, M. J. P. A. Janssens, J. A. M. van der Post, C. M. Licht
Research Article | published 23 Jul 2021 PLOS ONE
https://doi.org/10.1371/journal.pone.0255040

PLoS One
http://www.plosone.org/
[Accessed 24 Jul 2021]

Retraction: Tracking COVID-19 vaccine hesitancy and logistical challenges: A machine learning approach
Shantanu Dutta, Ashok Kumar, Moumita Dutta, Caolan Walsh
Retraction | published 22 Jul 2021 PLOS ONE
https://doi.org/10.1371/journal.pone.0255347

PLoS One
http://www.plosone.org/
[Accessed 24 Jul 2021]

Collective insights of public-private partnership impacts and sustainability: A qualitative analysis
Sheryl Strasser, Christine Stauber, Ritu Shrivastava, Patricia Riley, Karen O’Quin
Research Article | published 20 Jul 2021 PLOS ONE
https://doi.org/10.1371/journal.pone.0254495

PLoS One
http://www.plosone.org/
[Accessed 24 Jul 2021]

Association of Tdap vaccine guidelines with vaccine uptake during pregnancy
Julia D. DiTosto, Rebecca E. Weiss, Lynn M. Yee, Nevert Badreldin
Research Article | published 19 Jul 2021 PLOS ONE
https://doi.org/10.1371/journal.pone.0254863

PLoS One
http://www.plosone.org/
[Accessed 24 Jul 2021]

Modeling vaccination strategies in an Excel spreadsheet: Increasing the rate of vaccination is more effective than increasing the vaccination coverage for containing COVID-19
Mario Moisés Alvarez, Sergio Bravo-González, Grissel Trujillo-de Santiago
Research Article | published 19 Jul 2021 PLOS ONE
https://doi.org/10.1371/journal.pone.0254430

PNAS – Proceedings of the National Academy of Sciences of the United States of America
July 20, 2021; vol. 118 no. 29
https://www.pnas.org/content/118/29

Letters
Open Access
Optimal vaccination age varies across countries
Héctor Pifarré i Arolas, Enrique Acosta, and Mikko Myrskylä
PNAS July 20, 2021 118 (29) e2105987118; https://doi.org/10.1073/pnas.2105987118

PNAS – Proceedings of the National Academy of Sciences of the United States of America
July 20, 2021; vol. 118 no. 29
https://www.pnas.org/content/118/29

Transmission dynamics are crucial to COVID-19 vaccination policy
Jonathan Dushoff, Caroline Colijn, David J. D. Earn, and Benjamin M. Bolker
PNAS July 20, 2021 118 (29) e2105878118; https://doi.org/10.1073/pnas.2105878118

PNAS – Proceedings of the National Academy of Sciences of the United States of America
July 20, 2021; vol. 118 no. 29
https://www.pnas.org/content/118/29

Reply to Dushoff et al. and Pifarré i Arolas et al.: Age prioritization for COVID-19 vaccination does save lives and years of life
Joshua R. Goldstein, Thomas Cassidy, and Kenneth W. Wachter
PNAS July 20, 2021 118 (29) e2107654118; https://doi.org/10.1073/pnas.2107654118

PNAS – Proceedings of the National Academy of Sciences of the United States of America
July 20, 2021; vol. 118 no. 29
https://www.pnas.org/content/118/29

Psychological and Cognitive Sciences
Open Access
Transparent communication about negative features of COVID-19 vaccines decreases acceptance but increases trust
Michael Bang Petersen, Alexander Bor, Frederik Jørgensen, and Marie Fly Lindholt
PNAS July 20, 2021 118 (29) e2024597118; https://doi.org/10.1073/pnas.2024597118

Research Ethics
Volume 17 Issue 3, July 2021
http://journals.sagepub.com/toc/reab/current

Editorial
Research integrity: emphasising our commitment
Stuart G. Nicholls
First Published July 19, 2021
It is just over a year since the editors of this journal announced a broadening of the remit for submission. In doing so they made an explicit commitment to supporting work that examines research integrity issues. Furthering this commitment, we announce that Dr Edward Dove has joined Research Ethics as Associate Editor, with a focus on overseeing manuscripts that concern research integrity and/or misconduct matters.

As detailed in the previous editorial, research integrity is a counterpart to research ethics. Where research ethics focuses more on research governance at the programme or study level, research integrity takes as its focus the researcher themselves, emphasising the values and virtues of those conducting research. The Canadian Council of Academies research integrity framework, for example, articulates values of honesty, fairness, trust, accountability and openness as being key to research integrity (Davenport et al., 2010). A concrete example of efforts to improve research integrity is seen through the push for Open Science and research reporting guidelines (Glasziou et al., 2014; Nicholls et al., 2016). The use of reporting guidelines to facilitate more transparent and complete publication practices promotes what Masic (2012) calls ‘intellectual honesty’; being straightforward in description of the research process. When reporting guidelines are combined with what O’Neill (2002) has described as the ‘audit agenda’ and the ‘openness agenda’, the completeness and transparency of reporting can be assessed through peer review more easily. This, in turn, promotes trust in research findings and reporting, and ultimately the research process.

Research integrity is at the core of several papers in this issue. For instance, in their study of ethical issues in internet research and research using online data, Stommel and de Rijk examine how ethical issues are reported, and in what ways, as well as the steps that authors take to protect the privacy of the sources of publicly available online data. They note that almost two thirds of the 132 articles they examined did not report ethical considerations yet commonly took steps to anonymise data. Notably, the discussion of ethical issues was highly variable with discrepancies between ethics principles in theory and in practice.

Online platforms also feature in the work of Littler and Joy, although their focus is on the use of social media for research recruitment, specifically within LGBTQ communities. Littler and Joy examine the researcher role as gatekeepers. They reflect on what they have learned from their experience of negative hate speech posted in response to recruitment adverts on social media, and the impact it has on them as researchers. They conclude that it is incumbent upon researchers to become experts in the use and misuse of social media if they are to use these platforms for recruitment in research.

The impact of research on the researchers themselves, is also picked up by Podschuweit, who reports on quantitative covert observational research and the processes they employed to help student researchers deal with their personal discomfort in observing personal interactions. The findings show how mentally stressful covert observations can be for the student observers and suggestions are made for preparing students appropriately.

Finally, Reid et al. report on the development of a toolkit for global researchers designed to help navigate ethical challenges that they face when conducting research. They note that sharing experiences is an all too rare activity that is not generally encouraged within the competitive academic environment. Foundational to their work is the view that research integrity and research ethics matters are ongoing throughout the study, and not just about gaining ethics approval. The authors offer the 4P (place, people, principles and precedent) framework as a guiding structure to assist researchers approach ethical dilemmas that occur outside of the ethics approval process.

We hope that this collection of papers, as well as the other excellent manuscripts included in this issue, inspire readers to continue to examine and publish on matters of research integrity. We look forward to welcoming these at Research Ethics.

Science
23 July 2021 Vol 373, Issue 6553
http://www.sciencemag.org/current.dtl

Editorial
Colleges need vaccine mandates
By H. Holden Thorp
Summary
Finally, in the United States, colleges and universities are ramping up for a relatively normal school year. Most pandemic restrictions have been lifted and—barring any unforeseen new coronavirus variants—parents and students will soon be pulling up to residence halls and unloading their belongings. At many schools in “blue” states, there will be a great deal of confidence that good times are on the horizon as everyone there will have shown proof of vaccination against COVID-19. But for some public universities in “red” states, where vaccine mandates are not permitted, an aura of uncertainty will hang over the campus and the local community, a foreboding sense that another outbreak could be at hand.

Science
23 July 2021 Vol 373, Issue 6553
http://www.sciencemag.org/current.dtl

In-Depth
WHO chief pressures China on pandemic origin
By Jon Cohen
Science23 Jul 2021 : 378 Restricted Access
Agency director calls for lab audits and more studies of how SARS-CoV-2 emerged.
Summary
In a sharp tightening of the diplomatic screws, the director-general of the World Health Organization (WHO), Tedros Adhanom Ghebreyesus, is urging China to increase its transparency about the early days of the COVID-19 pandemic and allow greater access to its labs to help resolve the origin of SARS-CoV-2. Tedros also says WHO will create a new body to conduct the next phase of studies into the emergence of the virus, an unexpected move that concerns some scientists, including at least one member of an existing mission the agency organized to study COVID-19’s origin. Tedros called for more aggressively probing the two leading theories of how SARS-CoV-2 first infected humans and then emerged in Wuhan, China, in December 2019: that the virus made a natural “zoonotic” jump from an unknown animal species into humans or, more controversially, that it first infected a human during laboratory or field studies of coronaviruses found in animals. (An even more contentious theory suggests the virus was genetically engineered in a Wuhan lab.)

Science Translational Medicine
21 July 2021 Vol 13, Issue 603
https://stm.sciencemag.org/

Research Articles
The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to Plasmodium falciparum parasite resistance
By James M. Murithi, Cécile Pascal, Jade Bath, Xavier Boulenc, Nina F. Gnädig, Charisse Flerida A. Pasaje, Kelly Rubiano, Tomas Yeo, Sachel Mok, Sylvie Klieber, Paul Desert, María Belén Jiménez-Díaz, Jutta Marfurt, Mélanie Rouillier, Mohammed H. Cherkaoui-Rbati, Nathalie Gobeau, Sergio Wittlin, Anne-Catrin Uhlemann, Ric N. Price, Grennady Wirjanata, Rintis Noviyanti, Patrick Tumwebaze, Roland A. Cooper, Philip J. Rosenthal, Laura M. Sanz, Francisco Javier Gamo, Jayan Joseph, Shivendra Singh, Sridevi Bashyam, Jean Michel Augereau, Elie Giraud, Tanguy Bozec, Thierry Vermat, Gilles Tuffal, Jean-Michel Guillon, Jérôme Menegotto, Laurent Sallé, Guillaume Louit, Marie-José Cabanis, Marie Françoise Nicolas, Michel Doubovetzky, Rita Merino, Nadir Bessila, Iñigo Angulo-Barturen, Delphine Baud, Lidiya Bebrevska, Fanny Escudié, Jacquin C. Niles, Benjamin Blasco, Simon Campbell, Gilles Courtemanche, Laurent Fraisse, Alain Pellet, David A. Fidock, Didier Leroy
Science Translational Medicine21 Jul 2021 Full Access
We report an acylguanidine preclinical candidate with pharmacological features compatible with single low-dose malaria cure.
Antimalarial advance
The need for antimalarial drugs is urgent in the face of growing resistance to existing therapies. Murithi et al. characterized MMV688533, an acylguanidine identified from compounds inhibiting known human drug targets that were screened for activity against Plasmodium falciparum. MMV688533 showed rapid in vitro killing of multiple P. falciparum strains as well as P. vivax. A single dose of MMV688533 rapidly reduced parasitemia in a P. falciparum NSG mouse model of infection, and this agent displayed favorable pharmacokinetic and toxicity profiles. MMV688533 selected for only low-grade resistance, with resistant parasites remaining sensitive to existing antimalarials. These findings suggest that MMV688533 is a promising antimalarial candidate with a low resistance risk and the promise of a single-dose cure, which merits further study.

Vaccine
Volume 39, Issue 29 Pages 3785-4012 (29 June 2021)
https://www.sciencedirect.com/journal/vaccine/vol/39/issue/29

Commentaries
Discussion No access
COVID-19 vaccine hesitancy: Lessons from Israel
David Gurwitz
Pages 3785-3786

Vaccine
Volume 39, Issue 29 Pages 3785-4012 (29 June 2021)
https://www.sciencedirect.com/journal/vaccine/vol/39/issue/29

HPV vaccine: Expanding indications and global disparity
Christina Uwins, Sunu Cyriac, Geetu Bhandoria
Pages 3787-3789

Vaccine
Volume 39, Issue 29 Pages 3785-4012 (29 June 2021)
https://www.sciencedirect.com/journal/vaccine/vol/39/issue/29

Review article Abstract only
Methodologic approaches in studies using real-world data (RWD) to measure pediatric safety and effectiveness of vaccines administered to pregnant women: A scoping review
Tamar Lasky, Ann W. McMahon, Wei Hua, Richard Forshee
Pages 3814-3824

Vaccine
Volume 39, Issue 29 Pages 3785-4012 (29 June 2021)
https://www.sciencedirect.com/journal/vaccine/vol/39/issue/29

Review article Open access
Health inequities related to vaccination: An evidence map of potentially influential factors and systematic review of interventions
Allison Gates, Sholeh Rahman, Shannon Sim, Jennifer Pillay, … Lisa Hartling
Pages 3825-3833

Vaccine
Volume 39, Issue 29 Pages 3785-4012 (29 June 2021)
https://www.sciencedirect.com/journal/vaccine/vol/39/issue/29

Research article Abstract only
Optimising HPV vaccination communication to adolescents: A discrete choice experiment
Sandra Chyderiotis, Jonathan Sicsic, Jocelyn Raude, Isabelle Bonmarin, … Judith E. Mueller
Pages 3916-3925

Vaccine
Volume 39, Issue 29 Pages 3785-4012 (29 June 2021)
https://www.sciencedirect.com/journal/vaccine/vol/39/issue/29

Research article Abstract only
Association of vaccine hesitancy and immunization coverage rates in the European Union
Florian Stoeckel, Charlie Carter, Benjamin A. Lyons, Jason Reifler
Pages 3935-3939

Vaccines — Open Access Journal
http://www.mdpi.com/journal/vaccines

Open Access Article
Examining Vaccine Hesitancy in Sub-Saharan Africa: A Survey of the Knowledge and Attitudes among Adults to Receive COVID-19 Vaccines in Ghana
by Theophilus Acheampong et al
Vaccines 2021, 9(8), 814; https://doi.org/10.3390/vaccines9080814 – 22 Jul 2021
Abstract
The impact of COVID-19 vaccination programmes on disease transmission, morbidity and mortality relies heavily on the population’s willingness to accept the vaccine. We explore Ghanaian adult citizens’ vaccine hesitancy attitudes and identify the likelihood of participation or non-participation in the government’s effort to […

Vaccines — Open Access Journal
http://www.mdpi.com/journal/vaccines

Open Access Article
Who Is Willing to Get Vaccinated? A Study into the Psychological, Socio-Demographic, and Cultural Determinants of COVID-19 Vaccination Intentions
by Giuliani Mattia et al
Vaccines 2021, 9(8), 810; https://doi.org/10.3390/vaccines9080810 – 21 Jul 2021
Abstract
Crucial to the success of the COVID-19 vaccination campaign is the rate of people who adhere to it. This study aimed to investigate the reasons underlying people’s willingness to get vaccinated in a sample of Italian adults, considering the effects of different individual […]

Value in Health
July 2021 Volume 24 Issue 7 p917-1088
https://www.valueinhealthjournal.com/current

POLICY PERSPECTIVE
Measuring Attitudes About Genomic Medicine: Validation of the Genomic Orientation Scale (GO Scale)
Caroline Horrow, Joel E. Pacyna, Minji K. Lee, Richard R. Sharp
Published online: April 02, 2021
p1030-1037

Media/Policy Watch
This watch section is intended to alert readers to substantive news, analysis and opinion from the general media and selected think tanks and similar organizations on vaccines, immunization, global public health and related themes. Media Watch is not intended to be exhaustive, but indicative of themes and issues CVEP is actively tracking. This section will grow from an initial base of newspapers, magazines and blog sources, and is segregated from Journal Watch above which scans the peer-reviewed journal ecology.
We acknowledge the Western/Northern bias in this initial selection of titles and invite suggestions for expanded coverage. We are conservative in our outlook in adding news sources which largely report on primary content we are already covering above. Many electronic media sources have tiered, fee-based subscription models for access. We will provide full-text where content is published without restriction, but most publications require registration and some subscription level.
The sheer volume of vaccine and pandemic-related coverage is extraordinary. We will strive to present the most substantive analysis and commentary we encounter.

The Atlantic
http://www.theatlantic.com/magazine/
Accessed 24 Jul 2021
Ideas
Vaccinated America Has Had Enough
In the United States, this pandemic could be almost over by now. The reasons it’s still going are pretty clear.
By David Frum

BBC
http://www.bbc.co.uk/
Accessed 24 Jul 2021
[No new, unique, relevant content]

The Economist
http://www.economist.com/
Accessed 24 Jul 2021
Asia
Australia’s covid-19 strategy is being tested
The Delta variant combined with a low vaccination rate is causing trouble
July 24, 2021

No vaccine? No problem
Kazakhstan is awash in fake vaccination passports
Corruption helps spread covid-19
July 24, 2021
PEOPLE TEND to join dating apps to find love. But social-media users in Kazakhstan swipe right for less romantic services. On an array of platforms hustlers now do a roaring trade in fake vaccination documents.
“Vaccination passport without the vaccination” is how one account offers to register you in Kazakhstan’s e-government system…

Financial Times
https://www.ft.com/
Covid-19 vaccines
AstraZeneca admits ‘complicated’ Thai vaccine production launch
July 24, 2021

Coronavirus latest
Tennessee to restart vaccine outreach to teens following backlash
July 24, 2021

Coronavirus latest:
Iranian supreme leader receives second dose of domestically made vaccine
July 23, 2021

Forbes
https://www.forbes.com/
Accessed 24 Jul 2021
Jul 23, 2021
‘They’ve Seen The Lord’: Biden Praises GOP Governors For ‘Altar Call’ On Vaccines
By Andrew Solender Forbes Staff

Foreign Affairs
http://www.foreignaffairs.com/
Accessed 24 Jul 2021
[No new, unique, relevant content]

Foreign Policy
http://foreignpolicy.com/
Accessed 24 Jul 2021
Argument
Vaccines Are Japan’s New Tool to Counter China
Despite its worsening pandemic, Tokyo’s vaccine diplomacy has gained traction.
Argument | Samuel Ramani July 23, 2021, 2:43 PM

New Yorker
http://www.newyorker.com/
Accessed 24 Jul 2021
Letter from Biden’s Washington
Suddenly, (Some) Republicans Are All In on the Vaccine
The new G.O.P. politics of the pandemic follow the grim new math of the coronavirus for Red America.
By Susan B. Glasser
July 22, 2021

Annals of Medicine
Coexisting with the Coronavirus
COVID-19 is likely to become an endemic disease. How will our immune systems resist it?
By Katherine S. Xue
July 21, 2021

New York Times
http://www.nytimes.com/
Accessed 24 Jul 2021
World
Large Covid-related protests hit France, Italy and Australia.
Protesters’ targets include mandatory health passes in France and Italy, and lockdowns in Sydney, Melbourne and Adelaide.
By Aurelien Breeden July 24 2021

World
Hospitalized with Covid, a conservative Tennessee radio host shifts his message to urge vaccinations.
Phil Valentine is currently one of hundreds of Covid patients in Tennessee, which has seen a 77 percent increase in hospitalizations over the past two weeks.
By Jesus Jiménez
PRINT EDITION July 25, 2021

De Blasio Urges New York Businesses to Require Employee Vaccinations
The debate over mandates is intensifying as the highly contagious Delta variant of the coronavirus surges in many parts of the United States.
By Michael Gold, Emma G. Fitzsimmons and Michael D. Shear
PRINT EDITION |July 24, 2021, Page A1

Washington Post
https://www.washingtonpost.com/
[No new, unique, relevant content]

Think Tanks et al
 
 
Brookings [to 24 Jul 2021]
http://www.brookings.edu/
Africa in Focus
What lessons can Africa learn from India’s COVID-19 crisis?
Jamie MacLeod, Vera Songwe, Stephen Karingi, Hopestone Chavula, Jean Paul Boketsu Bofili, Sokunpanha You, and Veerawin Su
Friday, July 23, 2021

Brown Center Chalkboard
6 priorities for future research into COVID-19 and its effects on early learning
Christina Weiland, Erica Greenberg, Daphna Bassok, Anna Markowitz, Paola Guerrero Rosada, and Grace Luetmer
Tuesday, July 20, 2021
 
 
Center for Global Development [to 24 Jul 2021]
http://www.cgdev.org/page/press-center
Publication
[No new digest content identified]
 
 
Chatham House [to 24 Jul 2021]
https://www.chathamhouse.org/
Accessed 24 Jul 2021
[No new digest content identified]

 
 
CSIS
https://www.csis.org/
Accessed 24 Jul 2021
Upcoming Event
A Conversation with Dr. Anthony Fauci
August 2, 2021

Kaiser Family Foundation
https://www.kff.org/search/?post_type=press-release
July 21, 2021 News Release
Disparities in Global Vaccination Progress Are Large and Growing, With Low-Income Countries and Those in Africa Lagging Behind
A new KFF analysis finds that only 1% of those in low-income countries have received at least one vaccine dose compared to 51% in high-income countries, highlighting the substantial vaccine inequities around the world. The analysis examines these inequities by country income level and by region, finding large differences for each.
By region, Africa has the lowest coverage (2%) while Europe has the highest (40%), followed by the Americas (39%) and the Western Pacific (37%).
At the current pace of vaccinations, low-income countries are unlikely to meet the global vaccine targets set by the World Health Organization, World Trade Organization, International Monetary Fund, and World Bank of 40% coverage by the end of 2021, and 60% by mid-2022. Low-income countries would need to increase their daily vaccination rate by nearly 19 times to reach 40% coverage by the end of 2021. And while the Western Pacific, Europe, the Americas, and South-East Asia are ahead of schedule for reaching these vaccination goals, Africa would need to increase its rate of first dose administration by 8 times to reach 40% by the end of 2021.
The new analysis digs deeper into the growing equity gap and what this trend means for the future of global COVID-19 vaccination efforts…