Jun 06, 2009 Volume 373 Number 9679 Pages 1919 – 1996
Preliminary HPV vaccine results for women older than 25 years
Diane M Harper
After prophylactic human papillomavirus (HPV) vaccination, cost-effectiveness models predict that a reduction in cervical cancer will occur decades from now, but only when 90% of all girls aged 11–12 years have been vaccinated for many years, assuming vaccines confer lifelong protection. Should prophylactic vaccination protect women for less than 15 years, the incidence of cervical cancer will shift to women older than 25 years, with no overall decrease in cervical cancers from early vaccination.