The Lancet Infectious Disease
Nov 2009  Volume 9  Number 11  Pages 651 – 718
http://www.thelancet.com/journals/laninf/issue/current

Leading Edge
HIV vaccine trials and tribulations
The Lancet Infectious Diseases

Preview
The results released on Sept 24 of the RV144 trial of a vaccine against HIV offer a glimmer of hope in a field that has experienced many disappointments. The reported vaccine efficacy of 31% for prevention of HIV infection seems promising, but still leaves the prospect of immunisation as a practical public health intervention against HIV tantalisingly out of reach.