The Lancet Infectious Disease
Nov 2009 Volume 9 Number 11 Pages 651 – 718
HIV vaccine trials and tribulations
The Lancet Infectious Diseases
The results released on Sept 24 of the RV144 trial of a vaccine against HIV offer a glimmer of hope in a field that has experienced many disappointments. The reported vaccine efficacy of 31% for prevention of HIV infection seems promising, but still leaves the prospect of immunisation as a practical public health intervention against HIV tantalisingly out of reach.