The Lancet Infectious Disease
Nov 2009  Volume 9  Number 11  Pages 651 – 718
http://www.thelancet.com/journals/laninf/issue/current

Progress towards a dengue vaccine
Daniel P Webster, Jeremy Farrar, Sarah Rowland-Jones

The spread of dengue virus throughout the tropics represents a major, rapidly growing public health problem with an estimated 2.5 billion people at risk of dengue fever and the life-threatening disease, severe dengue. A safe and effective vaccine for dengue is urgently needed. The pathogenesis of severe dengue results from a complex interaction between the virus, the host, and, at least in part, immune-mediated mechanisms. Vaccine development has been slowed by fears that immunisation might predispose individuals to the severe form of dengue infection.