Clinical Infectious Diseases
1 November 2010  Volume 51, Number 9
http://www.journals.uchicago.edu/toc/cid/current

Editorial Commentary:
Cell Culture–Derived Influenza Vaccines: Has Their Time Come?
David I. Bernstein

Articles and Commentaries
Clinical Efficacy of Cell Culture–Derived and Egg‐Derived Inactivated Subunit Influenza Vaccines in Healthy Adults
Sharon Frey, Timo Vesikari, Agnieszka Szymczakiewicz-Multanowska, Maria Lattanzi, Allen Izu, Nicola Groth, and Sandra Holmes

This trial evaluated the efficacy of cell culture– and egg‐derived influenza vaccines versus placebo. The high overall vaccine efficacies, 83.8% and 78.4% against vaccine-like and 69.5% and 63.0% against all circulating influenza virus strains, support use of both vaccines for seasonal influenza vaccination.