Antimalarial drug resistance of Plasmodium falciparum in India

The Lancet Infectious Disease
Jan 2011  Volume 11 Number 1 Pages 1 – 72

Antimalarial drug resistance of Plasmodium falciparum in India: changes over time and space
Naman K Shah, Gajender PS Dhillon, Adtiya P Dash, Usha Arora, Steven R Meshnick, Neena Valecha

After the launch of the National Malaria Control Programme in 1953, the number of malaria cases reported in India fell to an all-time low of 0·1 million in 1965. However, the initial success could not be maintained and a resurgence of malaria began in the late 1960s. Resistance of Plasmodium falciparum to chloroquine was first reported in 1973 and increases in antimalarial resistance, along with rapid urbanisation and labour migration, complicated the challenge that India’s large geographical area and population size already pose for malaria control.