Cholera Vaccination

March 16, 2011, Vol 305, No. 11, pp 1061-1154

Cholera Vaccination
M. J. Friedrich
JAMA. 2011;305(11):1085.doi:10.1001/jama.2011.295

Oral cholera vaccination can help control cholera spread after an outbreak has begun, 2 new studies report.

Using existing data from a number of recent cholera outbreaks to simulate the number of cholera cases preventable by mass vaccination once an outbreak has occurred, researchers from the International Vaccine Institute (IVI) in Seoul, Korea, and other international institutions found that even a delayed response to vaccinate could be beneficial. (Reyburn R et al. PLoS Negl Trop Dis. 2011;5[1]:e952).

In a separate case-control study, researchers from the IVI and the National Institute of Hygiene and Epidemiology in Hanoi, Vietnam, found that giving 1 to 2 doses of vaccine after a cholera outbreak began in Hanoi in 2007-2008 was 76% protective against cholera in this setting (Anh DD et al. PLoS Negl Trop Dis. 2011;5[1]:e1006).

Recent outbreaks of the disease suggest that current global action plans against cholera are failing, but …