Vaccine Design Reaches the Atomic Level

Science Translational Medicine
13 July 2011 vol 3, issue 91

Perspectives: Vaccine Design
Vaccine Design Reaches the Atomic Level
Peter D. Kwong and Lawrence Shapiro
13 July 2011: 91ps29

The genetic diversity of pathogens presents a challenge to the development of broadly effective vaccines. In this issue, Scarselli et al. combine atomic-level structural information with genomics and classical vaccinology to design a single immunogen that elicits protective immunity against more than 300 natural variants of the bacterial pathogen meningococcus B. This accomplishment provides a glimpse of the power of structure-based vaccine design to create immunogens capable of eliciting protective responses against genetically diverse pathogens.